Detailed information NTG0490278

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ILP76_RS05315
• Genome accession: NZ_CP062469
• Coordinates: 1076399..1077442 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA - AMRF 4
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1071399..1082442

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ILP76_RS05285 (ILP76_05285)	-	1071884..1071994 (+)	111	WP_001790257.1	hypothetical protein	-
ILP76_RS05290 (ILP76_05290)	-	1072023..1072436 (+)	414	WP_025175030.1	hypothetical protein	-
ILP76_RS05295 (ILP76_05295)	-	1072867..1073853 (-)	987	WP_000999713.1	FUSC family protein	-
ILP76_RS05300 (ILP76_05300)	map	1074325..1075083 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
ILP76_RS05305 (ILP76_05305)	-	1075300..1075686 (+)	387	WP_001110179.1	hypothetical protein	-
ILP76_RS05310 (ILP76_05310)	liaF	1075701..1076402 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
ILP76_RS05315 (ILP76_05315)	vraS	1076399..1077442 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
ILP76_RS05320 (ILP76_05320)	vraR	1077432..1078061 (+)	630	WP_000153532.1	two-component system response regulator VraR	Regulator
ILP76_RS05325 (ILP76_05325)	-	1078173..1079390 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
ILP76_RS05330 (ILP76_05330)	-	1079668..1079943 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
ILP76_RS05335 (ILP76_05335)	-	1079950..1080414 (-)	465	WP_000567539.1	low molecular weight protein-tyrosine-phosphatase	-
ILP76_RS05340 (ILP76_05340)	-	1080561..1080761 (+)	201	WP_000180460.1	DUF1128 family protein	-
ILP76_RS05345 (ILP76_05345)	-	1080764..1082020 (+)	1257	WP_072398252.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=490278 ILP76_RS05315 WP_001017131.1 1076399..1077442(+) (vraS) [Staphylococcus aureus strain MRSA - AMRF 4]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=490278 ILP76_RS05315 WP_001017131.1 1076399..1077442(+) (vraS) [Staphylococcus aureus strain MRSA - AMRF 4]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1