Detailed information NTG0048997

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: STH8232_RS05810
• Genome accession: NC_017581
• Coordinates: 1113731..1114438 (-)
• Length: 235 a.a.
• NCBI ID: WP_011226084.1
• Uniprot ID: A0A060BQ44
• Organism: Streptococcus thermophilus JIM 8232
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1108731..1119438

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STH8232_RS05785 (STH8232_1340)	yidA	1109082..1109891 (+)	810	WP_011226081.1	sugar-phosphatase	-
STH8232_RS05790 (STH8232_1341)	-	1109893..1111107 (+)	1215	WP_004197368.1	aminoacyltransferase	-
STH8232_RS05795 (STH8232_1343)	-	1111159..1111520 (-)	362	Protein_1061	YbaN family protein	-
STH8232_RS05800 (STH8232_1344)	vicX	1111580..1112392 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
STH8232_RS05805 (STH8232_1345)	vicK	1112398..1113738 (-)	1341	WP_014621665.1	cell wall metabolism sensor histidine kinase VicK	Regulator
STH8232_RS05810 (STH8232_1346)	vicR	1113731..1114438 (-)	708	WP_011226084.1	response regulator YycF	Regulator
STH8232_RS05815 (STH8232_1347)	-	1114962..1115729 (+)	768	WP_011681207.1	amino acid ABC transporter ATP-binding protein	-
STH8232_RS05820 (STH8232_1348)	-	1115741..1116574 (+)	834	WP_011681208.1	transporter substrate-binding domain-containing protein	-
STH8232_RS05825 (STH8232_1349)	-	1116592..1117290 (+)	699	WP_014608374.1	amino acid ABC transporter permease	-
STH8232_RS05830 (STH8232_1350)	-	1117302..1117952 (+)	651	WP_014608375.1	amino acid ABC transporter permease	-
STH8232_RS05835 (STH8232_1351)	endA	1118023..1118904 (-)	882	WP_014621666.1	DNA/RNA non-specific endonuclease	Machinery gene
STH8232_RS05840 (STH8232_1352)	-	1118966..1119154 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27073.01 Da
• Isoelectric Point: 5.0130

>NTDB_id=48997 STH8232_RS05810 WP_011226084.1 1113731..1114438(-) (vicR) [Streptococcus thermophilus JIM 8232]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEVAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=48997 STH8232_RS05810 WP_011226084.1 1113731..1114438(-) (vicR) [Streptococcus thermophilus JIM 8232]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAGTTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACCGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

3D structure

• AlphaFold DB: A0A060BQ44

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.532	100	0.855
micA	Streptococcus pneumoniae Cp1015	80.258	99.149	0.796
covR	Streptococcus salivarius strain HSISS4	45.299	99.574	0.451
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.887	98.298	0.451
scnR	Streptococcus mutans UA159	38.559	100	0.387