Detailed information NTG0481443

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: D39N_RS10300
• Genome accession: NZ_CP061208
• Coordinates: 2041178..2041930 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain D39_P0
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2036178..2046930

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D39N_RS10865	-	2038611..2040214 (-)	1604	Protein_2015	YhgE/Pip domain-containing protein	-
D39N_RS10285 (D39N_02060)	-	2040393..2040935 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
D39N_RS10300 (D39N_02063)	comE	2041178..2041930 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
D39N_RS10305 (D39N_02064)	comD/comD1	2041927..2043252 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
D39N_RS10310 (D39N_02065)	comC/comC1	2043273..2043398 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
D39N_RS10320 (D39N_02067)	rlmH	2043680..2044159 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
D39N_RS10325 (D39N_02068)	htrA	2044342..2045523 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
D39N_RS10330 (D39N_02069)	spo0J	2045581..2046339 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=481443 D39N_RS10300 WP_000866065.1 2041178..2041930(-) (comE) [Streptococcus pneumoniae strain D39_P0]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=481443 D39N_RS10300 WP_000866065.1 2041178..2041930(-) (comE) [Streptococcus pneumoniae strain D39_P0]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACATATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408