Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   H7789_RS08840 Genome accession   NZ_CP060646
Coordinates   1810465..1811736 (-) Length   423 a.a.
NCBI ID   WP_109828658.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY1026     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1799419..1829352 1810465..1811736 within 0


Gene organization within MGE regions


Location: 1799419..1829352
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7789_RS08775 (H7789_08755) nrdG 1799419..1800033 (-) 615 WP_136018191.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  H7789_RS08780 (H7789_08760) - 1800048..1800542 (-) 495 WP_014407930.1 GNAT family N-acetyltransferase -
  H7789_RS08785 (H7789_08765) - 1800551..1801486 (-) 936 WP_228628181.1 Gfo/Idh/MocA family protein -
  H7789_RS08790 (H7789_08770) - 1801515..1801661 (-) 147 WP_002982210.1 hypothetical protein -
  H7789_RS08795 (H7789_08775) nrdD 1801843..1804041 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  H7789_RS08800 (H7789_08780) - 1804138..1805697 (-) 1560 WP_136289083.1 DUF2079 domain-containing protein -
  H7789_RS08805 (H7789_08785) - 1806110..1806415 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  H7789_RS08810 (H7789_08790) ruvX 1806427..1806846 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  H7789_RS08815 (H7789_08795) - 1806843..1807112 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  H7789_RS08825 (H7789_08800) - 1807284..1808417 (-) 1134 WP_137002476.1 ISAs1-like element IS1548 family transposase -
  H7789_RS08830 (H7789_08805) spx 1808551..1808949 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  H7789_RS08835 (H7789_08810) recA 1809240..1810376 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  H7789_RS08840 (H7789_08815) cinA 1810465..1811736 (-) 1272 WP_109828658.1 competence/damage-inducible protein A Machinery gene
  H7789_RS08845 (H7789_08820) - 1811805..1812365 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  H7789_RS08850 (H7789_08825) ruvA 1812375..1812971 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA -
  H7789_RS08855 (H7789_08830) - 1812973..1814193 (-) 1221 WP_228628185.1 MDR family MFS transporter -
  H7789_RS08860 (H7789_08835) mutL 1814204..1816186 (-) 1983 WP_136261141.1 DNA mismatch repair endonuclease MutL -
  H7789_RS08865 (H7789_08840) - 1816281..1817426 (-) 1146 WP_021299091.1 tyrosine-type recombinase/integrase -
  H7789_RS08870 (H7789_08845) - 1817702..1817845 (+) 144 WP_115219872.1 putative holin-like toxin -
  H7789_RS08875 (H7789_08850) - 1818684..1819451 (-) 768 WP_228628187.1 helix-turn-helix transcriptional regulator -
  H7789_RS08880 (H7789_08855) - 1819605..1819811 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  H7789_RS08885 (H7789_08860) - 1819845..1820612 (+) 768 WP_115219874.1 Bro-N domain-containing protein -
  H7789_RS08890 (H7789_08865) - 1820622..1821239 (+) 618 WP_136292716.1 Bro-N domain-containing protein -
  H7789_RS08895 (H7789_08870) - 1821266..1821508 (+) 243 WP_000648623.1 hypothetical protein -
  H7789_RS08900 (H7789_08875) - 1821766..1821939 (+) 174 WP_168388563.1 CopG family transcriptional regulator -
  H7789_RS08905 (H7789_08880) - 1822104..1822535 (+) 432 WP_136302445.1 hypothetical protein -
  H7789_RS08910 (H7789_08885) - 1822625..1822957 (+) 333 WP_136040200.1 hypothetical protein -
  H7789_RS08915 (H7789_08890) - 1822954..1823175 (+) 222 WP_010922763.1 hypothetical protein -
  H7789_RS08920 (H7789_08895) - 1823178..1823369 (+) 192 WP_136040053.1 hypothetical protein -
  H7789_RS08925 (H7789_08900) - 1823381..1823710 (+) 330 WP_228628189.1 hypothetical protein -
  H7789_RS08930 (H7789_08905) - 1823713..1823985 (+) 273 WP_001100459.1 hypothetical protein -
  H7789_RS08935 (H7789_08910) - 1823986..1824852 (+) 867 WP_136040054.1 primase alpha helix C-terminal domain-containing protein -
  H7789_RS08940 (H7789_08915) - 1824864..1826258 (+) 1395 WP_136270857.1 VapE domain-containing protein -
  H7789_RS08945 (H7789_08920) - 1826552..1826806 (+) 255 WP_001069294.1 hypothetical protein -
  H7789_RS08950 (H7789_08925) - 1826803..1826976 (+) 174 WP_011285281.1 hypothetical protein -
  H7789_RS08955 (H7789_08930) - 1826982..1827155 (+) 174 WP_047236056.1 hypothetical protein -
  H7789_RS08960 (H7789_08935) - 1827157..1827666 (+) 510 WP_136047602.1 hypothetical protein -
  H7789_RS08965 (H7789_08940) - 1827740..1828228 (+) 489 WP_228628190.1 hypothetical protein -
  H7789_RS08970 (H7789_08945) - 1828632..1828994 (+) 363 WP_011889234.1 DUF1492 domain-containing protein -
  H7789_RS08975 (H7789_08950) - 1828969..1829352 (+) 384 WP_136021348.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45988.81 Da        Isoelectric Point: 5.0771

>NTDB_id=477386 H7789_RS08840 WP_109828658.1 1810465..1811736(-) (cinA) [Streptococcus pyogenes strain TSPY1026]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDKQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIQNQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=477386 H7789_RS08840 WP_109828658.1 1810465..1811736(-) (cinA) [Streptococcus pyogenes strain TSPY1026]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATAAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTCAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.976

100

0.7
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461