Detailed information NTG0474200

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: H6X75_RS11165
• Genome accession: NZ_CP060156
• Coordinates: 2204850..2205602 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866058.1
• Uniprot ID: A0AAX3HG98
• Organism: Streptococcus pneumoniae strain PZ900700608
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2199850..2210602

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H6X75_RS11310	-	2202283..2203886 (-)	1604	Protein_2171	YhgE/Pip domain-containing protein	-
H6X75_RS11150 (H6X75_11140)	-	2204065..2204607 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
H6X75_RS11165 (H6X75_11155)	comE	2204850..2205602 (-)	753	WP_000866058.1	competence system response regulator transcription factor ComE	Regulator
H6X75_RS11170 (H6X75_11160)	comD/comD1	2205599..2206924 (-)	1326	WP_001813347.1	competence system sensor histidine kinase ComD	Regulator
H6X75_RS11175 (H6X75_11165)	comC/comC1	2206945..2207070 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
H6X75_RS11185 (H6X75_11175)	rlmH	2207353..2207832 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
H6X75_RS11190 (H6X75_11180)	htrA	2208015..2209196 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
H6X75_RS11195 (H6X75_11185)	spo0J	2209254..2210012 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29992.33 Da
• Isoelectric Point: 6.5073

>NTDB_id=474200 H6X75_RS11165 WP_000866058.1 2204850..2205602(-) (comE) [Streptococcus pneumoniae strain PZ900700608]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=474200 H6X75_RS11165 WP_000866058.1 2204850..2205602(-) (comE) [Streptococcus pneumoniae strain PZ900700608]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGTTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98.8	100	0.988
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408