Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   H6X75_RS08045 Genome accession   NZ_CP060156
Coordinates   1610790..1612769 (-) Length   659 a.a.
NCBI ID   WP_000614531.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700608     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1600961..1670135 1610790..1612769 within 0


Gene organization within MGE regions


Location: 1600961..1670135
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H6X75_RS08000 (H6X75_08010) - 1601137..1603074 (-) 1938 WP_000386627.1 sucrose-specific PTS transporter subunit IIBC -
  H6X75_RS08005 (H6X75_08015) - 1603450..1604904 (+) 1455 WP_000455299.1 sucrose-6-phosphate hydrolase -
  H6X75_RS08010 (H6X75_08020) - 1604885..1605850 (+) 966 WP_000226001.1 LacI family DNA-binding transcriptional regulator -
  H6X75_RS08015 (H6X75_08025) - 1605885..1607159 (-) 1275 WP_000704388.1 hydroxymethylglutaryl-CoA reductase, degradative -
  H6X75_RS08020 (H6X75_08030) - 1607159..1608331 (-) 1173 WP_000151959.1 hydroxymethylglutaryl-CoA synthase -
  H6X75_RS08025 (H6X75_08035) - 1608462..1608710 (-) 249 WP_001821065.1 hypothetical protein -
  H6X75_RS08030 (H6X75_08040) - 1608778..1609404 (-) 627 Protein_1603 transposase -
  H6X75_RS08035 (H6X75_08045) - 1609466..1609915 (-) 450 WP_000176924.1 threonine/serine exporter family protein -
  H6X75_RS08040 (H6X75_08050) - 1609917..1610675 (-) 759 WP_000392880.1 threonine/serine exporter ThrE family protein -
  H6X75_RS08045 (H6X75_08055) stkP 1610790..1612769 (-) 1980 WP_000614531.1 serine/threonine-protein kinase StkP Regulator
  H6X75_RS08050 (H6X75_08060) - 1612766..1613506 (-) 741 WP_000406253.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H6X75_RS08055 (H6X75_08065) rsmB 1613521..1614834 (-) 1314 WP_001813311.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  H6X75_RS08060 (H6X75_08070) fmt 1614827..1615762 (-) 936 WP_000163693.1 methionyl-tRNA formyltransferase -
  H6X75_RS08065 (H6X75_08075) - 1615775..1618171 (-) 2397 WP_241409270.1 primosomal protein N' -
  H6X75_RS08070 (H6X75_08080) rpoZ 1618237..1618551 (-) 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
  H6X75_RS08075 (H6X75_08085) gmk 1618576..1619202 (-) 627 WP_000775037.1 guanylate kinase -
  H6X75_RS08080 (H6X75_08090) - 1619332..1620945 (-) 1614 WP_000404940.1 ribonuclease Y -
  H6X75_RS08085 (H6X75_08095) - 1621289..1621999 (-) 711 Protein_1614 SIR2 family protein -
  H6X75_RS08090 (H6X75_08100) - 1622059..1623102 (-) 1044 WP_014262664.1 ORF6N domain-containing protein -
  H6X75_RS08095 (H6X75_08105) - 1623095..1624639 (-) 1545 WP_001098743.1 recombinase family protein -
  H6X75_RS08100 (H6X75_08110) - 1624641..1626323 (-) 1683 WP_000124510.1 recombinase family protein -
  H6X75_RS08105 (H6X75_08115) - 1626324..1627994 (-) 1671 WP_000042123.1 recombinase family protein -
  H6X75_RS08110 (H6X75_08120) - 1628137..1628367 (-) 231 WP_001860240.1 DUF6870 family protein -
  H6X75_RS08115 (H6X75_08125) - 1628833..1629243 (-) 411 WP_001123821.1 sigma-70 family RNA polymerase sigma factor -
  H6X75_RS08120 (H6X75_08130) - 1629451..1629873 (-) 423 WP_000458708.1 ATP-binding cassette domain-containing protein -
  H6X75_RS08125 (H6X75_08135) - 1630037..1631254 (-) 1218 WP_002368319.1 tyrosine-type recombinase/integrase -
  H6X75_RS08130 (H6X75_08140) - 1631336..1631539 (-) 204 WP_000814511.1 excisionase -
  H6X75_RS08135 - 1631523..1631774 (+) 252 WP_001845478.1 hypothetical protein -
  H6X75_RS08140 (H6X75_08145) - 1632000..1632230 (-) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  H6X75_RS08145 (H6X75_08150) - 1632227..1632649 (-) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  H6X75_RS08150 (H6X75_08155) - 1633154..1633375 (+) 222 Protein_1627 helix-turn-helix transcriptional regulator -
  H6X75_RS08155 (H6X75_08160) - 1633449..1636367 (-) 2919 WP_001240982.1 Tn3 family transposase -
  H6X75_RS08160 (H6X75_08165) - 1636371..1636925 (-) 555 WP_000576156.1 recombinase family protein -
  H6X75_RS08165 (H6X75_08170) erm(B) 1637280..1638017 (-) 738 WP_001038790.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
  H6X75_RS08170 (H6X75_08175) - 1638142..1638225 (-) 84 WP_001865637.1 23S rRNA methyltransferase attenuation leader peptide -
  H6X75_RS08175 (H6X75_08180) - 1638459..1638596 (+) 138 Protein_1632 XRE family transcriptional regulator -
  H6X75_RS08180 (H6X75_08185) - 1638656..1638823 (-) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  H6X75_RS08185 (H6X75_08190) tet(M) 1638942..1640861 (-) 1920 WP_241409274.1 tetracycline resistance ribosomal protection protein Tet(M) -
  H6X75_RS08190 (H6X75_08195) - 1640877..1640993 (-) 117 WP_001791010.1 tetracycline resistance determinant leader peptide -
  H6X75_RS08195 (H6X75_08200) - 1641238..1642173 (-) 936 WP_001224320.1 conjugal transfer protein -
  H6X75_RS08200 (H6X75_08205) - 1642170..1643171 (-) 1002 WP_241409276.1 bifunctional lysozyme/C40 family peptidase -
  H6X75_RS08205 (H6X75_08210) - 1643168..1645345 (-) 2178 WP_000804748.1 membrane protein -
  H6X75_RS08210 (H6X75_08215) - 1645348..1647795 (-) 2448 WP_002368314.1 ATP-binding protein -
  H6X75_RS08215 (H6X75_08220) - 1647779..1648171 (-) 393 WP_025186755.1 conjugal transfer protein -
  H6X75_RS08220 (H6X75_08225) - 1648185..1648682 (-) 498 WP_002368312.1 antirestriction protein ArdA -
  H6X75_RS08225 (H6X75_08230) - 1648799..1649020 (-) 222 WP_001009056.1 hypothetical protein -
  H6X75_RS08230 (H6X75_08235) mobT 1649063..1650266 (-) 1204 Protein_1643 MobT family relaxase -
  H6X75_RS08235 (H6X75_08240) - 1650289..1650441 (-) 153 WP_000879507.1 hypothetical protein -
  H6X75_RS08240 (H6X75_08245) - 1650444..1651838 (-) 1395 WP_241409280.1 FtsK/SpoIIIE domain-containing protein -
  H6X75_RS08245 (H6X75_08250) - 1651878..1652264 (-) 387 WP_000985040.1 YdcP family protein -
  H6X75_RS08250 (H6X75_08255) - 1652280..1652594 (-) 315 WP_000420681.1 YdcP family protein -
  H6X75_RS08255 (H6X75_08260) - 1652923..1653921 (-) 999 WP_001860234.1 ABC transporter ATP-binding protein -
  H6X75_RS08260 (H6X75_08265) - 1653918..1654646 (-) 729 WP_000431741.1 energy-coupling factor transporter transmembrane component T -
  H6X75_RS08265 (H6X75_08270) - 1654646..1655236 (-) 591 WP_014262669.1 MptD family putative ECF transporter S component -
  H6X75_RS08270 (H6X75_08275) - 1655262..1656986 (-) 1725 WP_000620708.1 ABC transporter ATP-binding protein -
  H6X75_RS08275 (H6X75_08280) - 1656983..1658752 (-) 1770 WP_000727577.1 ABC transporter ATP-binding protein -
  H6X75_RS08280 (H6X75_08285) - 1658859..1659473 (-) 615 WP_000166902.1 TetR/AcrR family transcriptional regulator -
  H6X75_RS08285 (H6X75_08290) mobC 1659763..1660113 (+) 351 WP_000013390.1 plasmid mobilization relaxosome protein MobC -
  H6X75_RS08290 (H6X75_08295) - 1660119..1661450 (+) 1332 WP_001018653.1 relaxase/mobilization nuclease domain-containing protein -
  H6X75_RS08295 (H6X75_08300) - 1661769..1662338 (-) 570 Protein_1656 single-stranded DNA-binding protein -

Sequence

Protein


Download         Length: 659 a.a.        Molecular weight: 72288.81 Da        Isoelectric Point: 9.0945

>NTDB_id=474164 H6X75_RS08045 WP_000614531.1 1610790..1612769(-) (stkP) [Streptococcus pneumoniae strain PZ900700608]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKAQAQTEHKSIK
NPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTE
ASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTV
LKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAG
TTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSVEGMVVEQSPRAGEKVDL
NKTRVKISIYKPKTTSATP

Nucleotide


Download         Length: 1980 bp        

>NTDB_id=474164 H6X75_RS08045 WP_000614531.1 1610790..1612769(-) (stkP) [Streptococcus pneumoniae strain PZ900700608]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTGTCAAACAGATTGGTCGAGGAGGCATGGCGGATGTCTA
CCTAGCCAAAGACTTAATCTTAGATGGGGAAGAAGTGGCAGTGAAGGTTCTGAGGACCAACTACCAGACGGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATCTAGACCATCCTCATATCGTTCGGATAACAGATATTGGT
GAGGAAGACGGTCAACAGTATCTTGCAATGGAGTATGTTGCTGGACTAGACCTCAAACGCTATATCAAGGAACATTATCC
TCTTTCTAATGAAGAAGCAGTCCGTATCATGGGACAAATTCTCTTGGCTATGCGCTTGGCCCATACTCGAGGAATTGTTC
ACAGGGACTTGAAACCTCAAAATATCCTTTTGACACCAGATGGGACTGCCAAGGTCACAGACTTTGGGATTGCTGTAGCC
TTTGCAGAGACAAGTCTGACCCAGACTAACTCGATGTTGGGCTCAGTTCATTACTTGTCACCAGAGCAGGCGCGTGGTTC
GAAGGCGACTGTGCAGAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGTTGACAGGCCATATCCCTTATGACG
GGGATAGCGCGGTGACCATTGCCCTCCAGCATTTCCAGAAACCCCTGCCGTCCGTTATTGCAGAAAATCCATCTGTACCT
CAGGCTTTAGAAAATGTTATTATCAAGGCGACTGCTAAAAAGTTGACCAATCGCTACCGCTCGGTTTCAGAGATGTATGT
GGACTTGTCTAGTAGCTTGTCCTACAATCGTAGAAATGAAAGTAAGTTAATCTTTGATGAAACGAGCAAGGCAGATACCA
AGACCTTGCCGAAGGTTTCTCAGAGTACCTTGACATCTATTCCTAAGGCTCAAGCGCAGACAGAACACAAATCAATCAAA
AACCCAAGCCAGGCTGTGACAGAGGAAACTTACCAACCACAAGCACCGAAAAAACATAGATTTAAGATGCGTTACCTGAT
TTTGTTGGCCAGCCTTGTATTGGTGGCAGCTTCTCTTATTTGGATACTATCCAGAACTCCTGCAACCATTGCCATTCCAG
ATGTGGCAGGTCAGACAGTTGCAGAGGCCAAGGCAACGCTCAAAAAAGCCAATTTTGAGATTGGTGAGGAGAAGACAGAG
GCTAGTGAAAAGGTGGAAGAAGGGCGGATTATCCGTACAGATCCTGGCGCTGGAACTGGTCGAAAAGAAGGAACGAAAAT
CAATCTGGTTGTCTCATCAGGCAAACAATCCTTCCAAATTAGTAATTATGTCGGCCGGAAATCTTCTGATGTTATCGCGG
AATTAAAAGAGAAAAAAGTTCCAGATAATTTGATTAAAATTGAGGAAGAAGAGTCGAATGAGAGTGAGGCTGGAACGGTC
TTGAAGCAAAGTCTACCAGAAGGTACGACCTATGACTTGAGCAAGGCAACTCAAATTGTTTTGACAGTAGCTAAAAAAGC
TACGACGATTCAATTAGGGAACTATATTGGACGGAACTCTACAGAAGTAATCTCAGAACTCAAGCAGAAGAAGGTTCCTG
AGAATTTGATTAAGATAGAGGAAGAAGAGTCCAGCGAAAGCGAACCAGGAACGATTATGAAACAAAGTCCAGGTGCCGGA
ACGACTTATGATGTGAGTAAACCTACTCAAATTGTCTTGACAGTAGCTAAAAAAGTTACAAGTGTTGCCATGCCGAGTTA
CATTGGTTCCAGCTTGGAGTTTACTAAGAACAATTTGATTCAAATTGTTGGGATTAAGGAAGCTAATATAGAAGTTGTAG
AAGTGACGACAGCGCCTGCAGGTAGTGTAGAAGGCATGGTTGTTGAACAAAGTCCTAGAGCAGGTGAAAAGGTAGACCTA
AATAAGACTAGAGTCAAGATTTCAATCTACAAACCTAAAACAACTTCAGCTACTCCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(513-577)

PASTA domain (PASTA)

(582-651)

PASTA domain (PASTA)

(371-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

99.697

100

0.997
  stkP Streptococcus pneumoniae D39

99.545

100

0.995
  stkP Streptococcus pneumoniae R6

99.545

100

0.995
  stkP Streptococcus pneumoniae Rx1

99.393

100

0.994
  pknB Streptococcus mutans UA159

52.901

88.923

0.47
  stkP/pknB Streptococcus salivarius strain HSISS4

51.807

88.164

0.457