NTDB

Overview

Name	comE/comE2	Type	Regulator
Locus tag	H1R75_RS08820	Genome accession	NZ_CP059471
Coordinates	1742981..1743709 (-)	Length	242 a.a.
NCBI ID	WP_024343524.1	Uniprot ID	A0A1G9NQG7
Organism	Streptococcus equinus strain MDC1
Function	activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1737981..1748709

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1R75_RS08790 (H1R75_08790)	-	1738316..1739257 (-)	942	WP_024343528.1	3'-5' exoribonuclease YhaM family protein	-
H1R75_RS08795 (H1R75_08795)	rmuC	1739247..1740461 (-)	1215	WP_371851905.1	DNA recombination protein RmuC	-
H1R75_RS08800 (H1R75_08800)	-	1740524..1741156 (-)	633	WP_024343527.1	thiamine diphosphokinase	-
H1R75_RS08805 (H1R75_08805)	rpe	1741149..1741811 (-)	663	WP_024343526.1	ribulose-phosphate 3-epimerase	-
H1R75_RS08810 (H1R75_08810)	rsgA	1741818..1742690 (-)	873	WP_027968346.1	ribosome small subunit-dependent GTPase A	-
H1R75_RS08820 (H1R75_08820)	comE/comE2	1742981..1743709 (-)	729	WP_024343524.1	LytR/AlgR family response regulator transcription factor	Regulator
H1R75_RS08825 (H1R75_08825)	comD/comD3	1744331..1745722 (-)	1392	WP_182001375.1	GHKL domain-containing protein	Regulator
H1R75_RS09875	comD/comD3	1745715..1746509 (-)	795	WP_235686232.1	sensor histidine kinase	Regulator
H1R75_RS08835 (H1R75_08835)	comD/comD3	1747107..1748489 (-)	1383	WP_235686233.1	GHKL domain-containing protein	Regulator
H1R75_RS08840 (H1R75_08840)	-	1748490..1748687 (-)	198	WP_182001376.1	hypothetical protein	-

Sequence

Protein

Download Length: 242 a.a. Molecular weight: 28281.51 Da Isoelectric Point: 6.4962

                                >NTDB_id=469849 H1R75_RS08820 WP_024343524.1 1742981..1743709(-) (comE/comE2) [Streptococcus equinus strain MDC1]

MIDIYVLEDNVNQQFRIERMIDELLDENQWDYRHFEIFSEPSHFPNFVEESCPQIFFLDIDINGDNKKGIEVAKKIREKS

RTATIVFVTTHSEFMLLTYRAQVSALDFIDKADEDSSIKINLKNCLRKVIENQALTMPQEFFVFENNKATIRIPMDEILY

FETAESHRLKLVTKSGQRNFYGSIKEVMAANQTFFRSHKSYLINLDNVVCLDKKNSLVHFVGGQSCLVSKKYIKELKLKI

GV

Nucleotide

Download Length: 729 bp

                                >NTDB_id=469849 H1R75_RS08820 WP_024343524.1 1742981..1743709(-) (comE/comE2) [Streptococcus equinus strain MDC1]

ATGATTGACATCTATGTATTGGAGGACAATGTAAATCAGCAATTTCGGATTGAAAGGATGATTGATGAACTACTCGATGA

AAATCAGTGGGACTATCGTCATTTTGAAATATTTAGTGAGCCGTCTCATTTTCCAAATTTTGTTGAGGAATCTTGCCCAC

AAATTTTTTTCTTAGATATTGATATCAATGGTGATAATAAAAAGGGAATTGAAGTCGCTAAGAAAATTAGGGAGAAATCT

AGAACAGCTACGATTGTTTTTGTGACGACGCATTCTGAGTTTATGTTGTTGACTTACCGAGCACAGGTTAGTGCACTTGA

TTTTATTGATAAGGCAGATGAAGACAGTTCGATAAAAATTAATTTAAAAAATTGTTTGCGAAAGGTCATCGAAAATCAGG

CTCTTACGATGCCACAGGAATTTTTTGTATTTGAAAATAATAAAGCTACTATTCGTATTCCGATGGATGAAATTCTTTAT

TTTGAAACAGCTGAAAGTCATCGACTGAAGTTGGTTACAAAGTCGGGACAACGTAATTTTTATGGTTCAATCAAAGAAGT

AATGGCTGCTAATCAGACCTTTTTTAGAAGCCACAAATCGTATCTGATTAATCTTGATAATGTTGTGTGCTTAGATAAAA

AGAATAGTCTGGTGCATTTTGTCGGTGGTCAATCTTGCCTTGTTTCAAAGAAATACATTAAAGAATTAAAGTTGAAAATA

GGTGTTTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-114)

LytTr DNA-binding domain (LytTR)

(149-239)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A1G9NQG7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/comE2	Streptococcus equinus JB1	74.167	99.174	0.736
comE/comE1	Streptococcus equinus JB1	44.118	98.347	0.434
comE/blpR	Streptococcus mutans UA159	39.754	100	0.401
comE/comE2	Streptococcus gordonii strain NCTC7865	38.367	100	0.388
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.367	100	0.388

Detailed information NTG0469849