Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6G22_RS02470 Genome accession   NZ_CP065737
Coordinates   441173..441841 (-) Length   222 a.a.
NCBI ID   WP_211279595.1    Uniprot ID   -
Organism   Lactococcus lactis strain FDAARGOS_865     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 436173..446841
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6G22_RS02455 (I6G22_02455) yidD 437437..437703 (-) 267 WP_010906087.1 membrane protein insertion efficiency factor YidD -
  I6G22_RS02460 (I6G22_02460) - 437820..439562 (-) 1743 WP_025016942.1 1-deoxy-D-xylulose-5-phosphate synthase -
  I6G22_RS02465 (I6G22_02465) ciaH 439710..441080 (-) 1371 WP_023189696.1 sensor histidine kinase Regulator
  I6G22_RS02470 (I6G22_02470) ciaR 441173..441841 (-) 669 WP_211279595.1 response regulator transcription factor Regulator
  I6G22_RS02475 (I6G22_02475) - 442019..442993 (-) 975 WP_025016944.1 LacI family DNA-binding transcriptional regulator -
  I6G22_RS02480 (I6G22_02480) - 443146..445401 (-) 2256 WP_025016945.1 glycoside hydrolase family 65 protein -

Sequence

Protein


Download         Length: 222 a.a.        Molecular weight: 25514.44 Da        Isoelectric Point: 4.4864

>NTDB_id=450985 I6G22_RS02470 WP_211279595.1 441173..441841(-) (ciaR) [Lactococcus lactis strain FDAARGOS_865]
MIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTA
KESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVV
YLMQNQNVVLPKEQIFDRIWGYDSDITVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Nucleotide


Download         Length: 669 bp        

>NTDB_id=450985 I6G22_RS02470 WP_211279595.1 441173..441841(-) (ciaR) [Lactococcus lactis strain FDAARGOS_865]
ATGATTAAAATTTTATTAGTGGAGGATGATTTATCACTCTCAAAATCTGTTTACGATTTCTTAAAATCATTTGCGCAAGT
CAAACAGGTTTATGATGGAGTTGAAGGACTCTATGAGGCAGAATTGGGAATTTATGATTTAATTTTGCTTGATTTAATGC
TTCCAGAAAAGAATGGTTTTGAAGTCTTAAAGGAATTACGTGAGCAAAATGTAGATACACCAGTCTTAATCATGACTGCT
AAGGAATCTTTGGATGATAAAATGCACGGATTCGACATTGGAGCAGATGATTATTTAACAAAACCTTTCTATTTAGATGA
ACTAAAAGCACGTATTCAAGCACTTTTGAAACGGACAGGTAAATTAGAAGATTCAAACGGTTTAACTTATGGAAATATTC
GTTTGAATTTATCAAATAAATCAACTTTAGTTGATGATCAACCTGTTGATTTAATCGGAAAAGAATTTGATTTAGTCGTT
TATTTAATGCAAAATCAAAATGTTGTTTTGCCAAAAGAGCAAATTTTTGACCGGATTTGGGGCTATGACAGTGATATAAC
AGTAACTGTTGTTGAAGTTTATATGAGTAAAATTCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATCTTTCAACCT
TGCGAAATGTTGGCTATATCTTGAGATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-221)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

73.874

100

0.739
  ciaR Streptococcus pneumoniae D39

73.874

100

0.739
  ciaR Streptococcus pneumoniae R6

73.874

100

0.739
  ciaR Streptococcus pneumoniae TIGR4

73.874

100

0.739
  ciaR Streptococcus mutans UA159

72.072

100

0.721
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.392
  covR Streptococcus salivarius strain HSISS4

38.222

100

0.387
  vicR Streptococcus mutans UA159

35.193

100

0.369
  micA Streptococcus pneumoniae Cp1015

34.914

100

0.365