Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   GE021_RS04995 Genome accession   NZ_CP053792
Coordinates   987426..988100 (+) Length   224 a.a.
NCBI ID   WP_003048303.1    Uniprot ID   A0A2D4DMP2
Organism   Streptococcus canis strain HL_77_1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 982426..993100
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GE021_RS04985 (GE021_004985) - 982993..985530 (+) 2538 WP_125074025.1 M1 family metallopeptidase -
  GE021_RS04990 (GE021_004990) - 985608..987134 (-) 1527 WP_125075051.1 IS1182 family transposase -
  GE021_RS04995 (GE021_004995) ciaR 987426..988100 (+) 675 WP_003048303.1 response regulator transcription factor Regulator
  GE021_RS05000 (GE021_005000) ciaH 988093..989403 (+) 1311 WP_125074024.1 cell wall metabolism sensor histidine kinase WalK Regulator
  GE021_RS05005 (GE021_005005) rpsT 989848..990096 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  GE021_RS05010 (GE021_005010) coaA 990150..991070 (-) 921 WP_125074023.1 type I pantothenate kinase -
  GE021_RS05015 (GE021_005015) - 991339..991938 (+) 600 WP_125074022.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25693.73 Da        Isoelectric Point: 4.4740

>NTDB_id=447277 GE021_RS04995 WP_003048303.1 987426..988100(+) (ciaR) [Streptococcus canis strain HL_77_1]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLSFGNVVVDLRRKEVQVDGEPIELLGKEFDLLVY
ILQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTGFVDKLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=447277 GE021_RS04995 WP_003048303.1 987426..988100(+) (ciaR) [Streptococcus canis strain HL_77_1]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGTTTATCGAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
GATGCAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGATCTCATGT
TACCAGAAAAAAATGGTTTTCAAGTCTTAAAAGAATTGCGGGAAAAAGATATTAAAATTCCGGTTTTGATTATGACAGCC
AAAGAAAGCATAGATGATAAGGGACATGGGTTTGAACTAGGAGCAGATGATTATCTAACCAAGCCGTTTTACCTTGAAGA
ATTAAAGATGCGAATCCAGGCCCTGTTAAAACGTACGGGCAAATTCACTGATAAAAATCTAAGTTTTGGTAATGTAGTGG
TGGATTTAAGACGAAAAGAAGTTCAAGTCGATGGGGAACCCATTGAGCTATTGGGAAAAGAGTTTGACTTATTGGTTTAC
ATATTGCAAAACCAAAATGTGATCTTACCAAAGACCCAAATTTTTGATCGTTTATGGGGGTTTGACAGCGACACGACAAT
CTCAGTTGTAGAGGTTTATGTCTCTAAGATTAGAAAAAAATTAAAAGGTACTGGTTTTGTTGACAAACTCCAAACCCTGA
GAAGTGTAGGTTATATTCTAAAAAACAATGAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2D4DMP2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus mutans UA159

83.333

99.107

0.826
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  covR Streptococcus salivarius strain HSISS4

36.726

100

0.371
  micA Streptococcus pneumoniae Cp1015

34.615

100

0.362
  vicR Streptococcus mutans UA159

34.615

100

0.362