NTDB

Overview

Name	comYH	Type	Machinery gene
Locus tag	HKM25_RS10305	Genome accession	NZ_CP053210
Coordinates	2006501..2007454 (-)	Length	317 a.a.
NCBI ID	WP_000345121.1	Uniprot ID	A0A4J2CH53
Organism	Streptococcus pneumoniae strain 6A-10
Function	dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2001501..2012454

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKM25_RS10280 (HKM25_2105)	-	2002262..2002885 (-)	624	WP_000932660.1	hypothetical protein	-
HKM25_RS10285 (HKM25_2106)	jag	2002936..2003922 (-)	987	WP_000260015.1	RNA-binding cell elongation regulator Jag/EloR	-
HKM25_RS10290 (HKM25_2107)	-	2003941..2004765 (-)	825	WP_000727904.1	membrane protein insertase YidC	-
HKM25_RS10295 (HKM25_2108)	rnpA	2004740..2005111 (-)	372	WP_000739246.1	ribonuclease P protein component	-
HKM25_RS11980 (HKM25_2109)	-	2005128..2005259 (-)	132	WP_000768904.1	hypothetical protein	-
HKM25_RS10300 (HKM25_2110)	-	2005260..2006450 (-)	1191	WP_054362660.1	acetate kinase	-
HKM25_RS10305 (HKM25_2111)	comYH	2006501..2007454 (-)	954	WP_000345121.1	class I SAM-dependent methyltransferase	Machinery gene
HKM25_RS10310	-	2007515..2008108 (-)	594	Protein_2026	methyltransferase domain-containing protein	-
HKM25_RS10315 (HKM25_2114)	comGG/cglG	2008245..2008658 (-)	414	WP_000265630.1	competence type IV pilus minor pilin ComGG	Machinery gene
HKM25_RS10320 (HKM25_2115)	comGF/cglF	2008636..2009097 (-)	462	WP_000250545.1	competence type IV pilus minor pilin ComGF	Machinery gene
HKM25_RS10325 (HKM25_2116)	comGE/cglE	2009060..2009362 (-)	303	WP_000413382.1	competence type IV pilus minor pilin ComGE	Machinery gene
HKM25_RS10330 (HKM25_2117)	comGD/cglD	2009325..2009729 (-)	405	WP_000588005.1	competence type IV pilus minor pilin ComGD	Machinery gene
HKM25_RS10335 (HKM25_2118)	comGC/cglC	2009722..2010048 (-)	327	WP_000738635.1	comG operon protein ComGC	Machinery gene
HKM25_RS10340 (HKM25_2119)	comGB/cglB	2010050..2011066 (-)	1017	WP_078151629.1	competence type IV pilus assembly protein ComGB	Machinery gene
HKM25_RS10345 (HKM25_2120)	comGA/cglA/cilD	2011014..2011955 (-)	942	WP_000249555.1	competence type IV pilus ATPase ComGA	Machinery gene
HKM25_RS10350 (HKM25_2121)	-	2012031..2012396 (-)	366	WP_000286415.1	DUF1033 family protein	-

Sequence

Protein

Download Length: 317 a.a. Molecular weight: 35689.92 Da Isoelectric Point: 4.2665

                                >NTDB_id=443472 HKM25_RS10305 WP_000345121.1 2006501..2007454(-) (comYH) [Streptococcus pneumoniae strain 6A-10]

MDFEKIEQAYTYLLENVQVIQSDLATNFYDALVEQNSIYLDGETELNQVKDNNQALKRLALRKEEWLKTYQFLLMKAGQT

EPLQANHQFTPDAIALLLVFIVEELFKEEEITILEMGSGMGILGATFLTSLDKKVDYLGMEMDDLLIDLAASMADVIGLQ

AGFVQGDAVRPQMLKESDVVISDLPVGYYPDDAVASRHQVASSQEHTYAHHLLMEQGLKYLKSDGYAIFLAPSDLLTSPQ

SDLLKVWLKEEASLVAMISLPENLFANAKQSKTIFILQKKSEIAVEPFVYPLASLQDASVLMKFKENFQKWTQGTEI

Nucleotide

Download Length: 954 bp

                                >NTDB_id=443472 HKM25_RS10305 WP_000345121.1 2006501..2007454(-) (comYH) [Streptococcus pneumoniae strain 6A-10]

ATGGATTTTGAAAAAATTGAACAAGCCTATACCTATTTACTAGAGAATGTCCAAGTCATCCAAAGTGATTTGGCGACCAA

CTTTTATGACGCCTTGGTGGAGCAAAACAGCATCTATCTGGATGGTGAAACTGAGCTAAACCAGGTCAAAGACAACAATC

AGGCCCTTAAGCGTTTAGCACTACGCAAAGAAGAATGGCTCAAGACCTACCAGTTTCTCTTGATGAAGGCTGGGCAAACA

GAACCCTTGCAGGCCAATCACCAGTTTACACCAGATGCCATTGCTTTGCTTTTGGTGTTTATTGTGGAAGAGTTGTTTAA

AGAGGAGGAAATTACTATCCTCGAAATGGGTTCTGGGATGGGAATTCTAGGCGCTACTTTCTTGACCTCGCTTGATAAAA

AGGTGGATTACTTGGGAATGGAAATGGATGATTTGCTGATTGATCTGGCAGCTAGCATGGCAGATGTAATTGGTTTGCAG

GCTGGCTTTGTCCAAGGAGATGCCGTTCGTCCACAAATGCTCAAAGAAAGCGATGTGGTCATCAGTGACTTGCCTGTTGG

CTATTATCCTGATGATGCCGTTGCGTCGCGCCATCAAGTTGCTTCTAGCCAAGAACATACTTACGCCCATCACTTGCTCA

TGGAACAAGGGCTTAAGTACCTCAAGTCAGACGGATACGCTATTTTTCTAGCTCCGAGTGATTTGTTGACCAGTCCTCAA

AGTGATTTGTTGAAAGTCTGGTTGAAAGAGGAGGCAAGTCTGGTTGCTATGATTAGTTTACCTGAAAATCTCTTTGCTAA

TGCTAAACAATCTAAGACTATTTTTATCCTACAGAAGAAAAGTGAAATAGCAGTAGAGCCTTTTGTTTATCCACTTGCTA

GCTTGCAAGATGCAAGTGTTTTAATGAAATTTAAAGAAAATTTTCAAAAATGGACTCAAGGTACTGAAATATAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(69-282)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4J2CH53

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comYH	Streptococcus mutans UA140	54.633	98.738	0.539
comYH	Streptococcus mutans UA159	54.313	98.738	0.536

Detailed information NTG0443472