NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	HKM25_RS04515	Genome accession	NZ_CP053210
Coordinates	890800..891450 (+)	Length	216 a.a.
NCBI ID	WP_000387336.1	Uniprot ID	-
Organism	Streptococcus pneumoniae strain 6A-10
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 885800..896450

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKM25_RS04480 (HKM25_917)	-	886283..886498 (+)	216	WP_001232082.1	YozE family protein	-
HKM25_RS04485 (HKM25_918)	-	886584..887552 (+)	969	WP_000658191.1	PhoH family protein	-
HKM25_RS04495 (HKM25_919)	-	887745..888245 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
HKM25_RS04500 (HKM25_920)	-	888248..888622 (+)	375	Protein_904	TfoX/Sxy family protein	-
HKM25_RS04505	ald	888876..889986 (-)	1111	Protein_905	alanine dehydrogenase	-
HKM25_RS04510 (HKM25_924)	-	890163..890732 (+)	570	WP_000443749.1	GNAT family N-acetyltransferase	-
HKM25_RS04515 (HKM25_925)	comEA/celA/cilE	890800..891450 (+)	651	WP_000387336.1	ComEA family DNA-binding protein	Machinery gene
HKM25_RS04520 (HKM25_926)	comEC/celB	891434..893674 (+)	2241	WP_000942396.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
HKM25_RS04525 (HKM25_927)	-	893801..894064 (+)	264	WP_000747853.1	hypothetical protein	-
HKM25_RS04530 (HKM25_928)	-	894096..894683 (+)	588	WP_000933543.1	ABC transporter ATP-binding protein	-
HKM25_RS04535 (HKM25_929)	-	894687..895868 (+)	1182	WP_000655948.1	ABC transporter permease	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23189.54 Da Isoelectric Point: 5.5171

                                >NTDB_id=443435 HKM25_RS04515 WP_000387336.1 890800..891450(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 6A-10]

MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG

AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA

SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=443435 HKM25_RS04515 WP_000387336.1 890800..891450(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 6A-10]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT

TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT

TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT

GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC

AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG

AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC

AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG

CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA

CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae D39	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae R6	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.222	100	0.972
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	91.204	100	0.912
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361

Detailed information NTG0443435