Detailed information NTG0443436

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: HKM25_RS04520
• Genome accession: NZ_CP053210
• Coordinates: 891434..893674 (+)
• Length: 746 a.a.
• NCBI ID: WP_000942396.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 6A-10
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 886434..898674

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HKM25_RS04485 (HKM25_918)	-	886584..887552 (+)	969	WP_000658191.1	PhoH family protein	-
HKM25_RS04495 (HKM25_919)	-	887745..888245 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
HKM25_RS04500 (HKM25_920)	-	888248..888622 (+)	375	Protein_904	TfoX/Sxy family protein	-
HKM25_RS04505	ald	888876..889986 (-)	1111	Protein_905	alanine dehydrogenase	-
HKM25_RS04510 (HKM25_924)	-	890163..890732 (+)	570	WP_000443749.1	GNAT family N-acetyltransferase	-
HKM25_RS04515 (HKM25_925)	comEA/celA/cilE	890800..891450 (+)	651	WP_000387336.1	ComEA family DNA-binding protein	Machinery gene
HKM25_RS04520 (HKM25_926)	comEC/celB	891434..893674 (+)	2241	WP_000942396.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
HKM25_RS04525 (HKM25_927)	-	893801..894064 (+)	264	WP_000747853.1	hypothetical protein	-
HKM25_RS04530 (HKM25_928)	-	894096..894683 (+)	588	WP_000933543.1	ABC transporter ATP-binding protein	-
HKM25_RS04535 (HKM25_929)	-	894687..895868 (+)	1182	WP_000655948.1	ABC transporter permease	-
HKM25_RS04540 (HKM25_931)	infC	896175..896705 (+)	531	WP_000848180.1	translation initiation factor IF-3	-
HKM25_RS04545 (HKM25_932)	rpmI	896738..896938 (+)	201	WP_001125943.1	50S ribosomal protein L35	-
HKM25_RS04550 (HKM25_933)	rplT	896990..897349 (+)	360	WP_000124836.1	50S ribosomal protein L20	-
HKM25_RS04555 (HKM25_934)	-	897407..897787 (+)	381	WP_000157154.1	VOC family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84472.80 Da
• Isoelectric Point: 9.2649

>NTDB_id=443436 HKM25_RS04520 WP_000942396.1 891434..893674(+) (comEC/celB) [Streptococcus pneumoniae strain 6A-10]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKTIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLQLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVTSESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
HPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEMTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMTVGEYLPIFGSQLEVLSPREIGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=443436 HKM25_RS04520 WP_000942396.1 891434..893674(+) (comEC/celB) [Streptococcus pneumoniae strain 6A-10]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAACAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGTATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCAATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTACTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
CTCACAGGTGACAAGTAGGCCTCTAGTCTTTGGACAACCCAATGCATGGCTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCCTTACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTTGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTCGGTGGCAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGATGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGTACTTGCCCATTTTCG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGGAAATTGGAGATGGAGGACACGATGACACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTATCGAACTGACCAGCAAGGAGCTATACGTTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGCGTTCGATA
G

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-176)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-637)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus pneumoniae TIGR4	98.525	100	0.985
comEC/celB	Streptococcus pneumoniae Rx1	97.453	100	0.975
comEC/celB	Streptococcus pneumoniae D39	97.453	100	0.975
comEC/celB	Streptococcus pneumoniae R6	97.453	100	0.975
comEC/celB	Streptococcus mitis SK321	91.957	100	0.92
comEC/celB	Streptococcus mitis NCTC 12261	91.946	99.866	0.918
comEC	Lactococcus lactis subsp. cremoris KW2	44.265	99.33	0.44