Detailed information
Bioinformatically predicted
Overview
| Name | comGA/cglA | Type | Machinery gene |
| Locus tag | HG697_RS00780 | Genome accession | NZ_CP051623 |
| Coordinates | 127082..128023 (+) | Length | 313 a.a. |
| NCBI ID | WP_003055265.1 | Uniprot ID | A0AB33R474 |
| Organism | Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A19 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 128004..169130 | 127082..128023 | flank | -19 |
Gene organization within MGE regions
Location: 127082..169130
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HG697_RS00780 (HG697_00785) | comGA/cglA | 127082..128023 (+) | 942 | WP_003055265.1 | competence type IV pilus ATPase ComGA | Machinery gene |
| HG697_RS00785 (HG697_00790) | comYB | 127959..128990 (+) | 1032 | WP_015057201.1 | competence type IV pilus assembly protein ComGB | Machinery gene |
| HG697_RS00790 (HG697_00795) | comYC | 128992..129318 (+) | 327 | WP_003055259.1 | competence type IV pilus major pilin ComGC | Machinery gene |
| HG697_RS00795 (HG697_00800) | - | 129355..130809 (-) | 1455 | WP_139818685.1 | recombinase family protein | - |
| HG697_RS00800 (HG697_00805) | - | 130946..131437 (-) | 492 | WP_170078856.1 | hypothetical protein | - |
| HG697_RS00805 (HG697_00810) | - | 131448..132218 (-) | 771 | WP_003055282.1 | XRE family transcriptional regulator | - |
| HG697_RS00810 (HG697_00815) | - | 132419..132622 (+) | 204 | WP_003058516.1 | helix-turn-helix transcriptional regulator | - |
| HG697_RS00815 (HG697_00820) | - | 132911..133060 (+) | 150 | WP_003058552.1 | hypothetical protein | - |
| HG697_RS00820 (HG697_00825) | - | 133100..133447 (+) | 348 | WP_065359272.1 | DNA-binding protein | - |
| HG697_RS00825 (HG697_00830) | - | 133713..134213 (+) | 501 | WP_143935354.1 | hypothetical protein | - |
| HG697_RS00830 (HG697_00835) | - | 134216..134908 (+) | 693 | WP_170078858.1 | ERF family protein | - |
| HG697_RS00835 (HG697_00840) | - | 135052..136074 (+) | 1023 | WP_170078860.1 | DUF1351 domain-containing protein | - |
| HG697_RS00840 (HG697_00845) | - | 136074..136628 (+) | 555 | WP_003058546.1 | MazG-like family protein | - |
| HG697_RS00845 (HG697_00850) | - | 136615..136809 (+) | 195 | WP_115261906.1 | hypothetical protein | - |
| HG697_RS00850 (HG697_00855) | - | 136796..137317 (+) | 522 | WP_170078862.1 | hypothetical protein | - |
| HG697_RS00855 (HG697_00860) | - | 137326..138024 (+) | 699 | WP_003058504.1 | site-specific DNA-methyltransferase | - |
| HG697_RS00860 (HG697_00865) | - | 138047..138325 (+) | 279 | WP_037588195.1 | hypothetical protein | - |
| HG697_RS00865 (HG697_00870) | - | 138339..138701 (+) | 363 | WP_240954826.1 | hypothetical protein | - |
| HG697_RS00870 (HG697_00875) | - | 138688..138891 (+) | 204 | WP_003058550.1 | hypothetical protein | - |
| HG697_RS00875 (HG697_00880) | - | 138888..139325 (+) | 438 | WP_003058575.1 | helix-turn-helix domain-containing protein | - |
| HG697_RS00880 (HG697_00885) | - | 139338..139769 (+) | 432 | WP_170078866.1 | hypothetical protein | - |
| HG697_RS00885 (HG697_00890) | - | 139771..140508 (+) | 738 | WP_170078868.1 | hypothetical protein | - |
| HG697_RS00890 (HG697_00895) | - | 140528..140857 (+) | 330 | WP_170078870.1 | hypothetical protein | - |
| HG697_RS00895 (HG697_00900) | - | 141064..141240 (+) | 177 | WP_165737297.1 | hypothetical protein | - |
| HG697_RS00900 (HG697_00905) | - | 141242..141580 (+) | 339 | WP_170078873.1 | DUF1372 family protein | - |
| HG697_RS10430 | - | 141580..141903 (+) | 324 | WP_240954820.1 | hypothetical protein | - |
| HG697_RS00910 (HG697_00915) | - | 141896..142126 (+) | 231 | WP_170078877.1 | hypothetical protein | - |
| HG697_RS00915 (HG697_00920) | - | 142123..142533 (+) | 411 | WP_170078879.1 | hypothetical protein | - |
| HG697_RS00920 (HG697_00925) | - | 142526..142906 (+) | 381 | WP_170078881.1 | hypothetical protein | - |
| HG697_RS00925 (HG697_00930) | - | 142961..143644 (+) | 684 | WP_240954821.1 | DUF4417 domain-containing protein | - |
| HG697_RS00930 (HG697_00935) | - | 143641..144024 (+) | 384 | WP_170078883.1 | hypothetical protein | - |
| HG697_RS00935 (HG697_00940) | - | 144217..144696 (+) | 480 | WP_003058573.1 | terminase small subunit | - |
| HG697_RS00940 (HG697_00945) | - | 144683..145996 (+) | 1314 | WP_170078885.1 | PBSX family phage terminase large subunit | - |
| HG697_RS00945 (HG697_00950) | - | 146009..147586 (+) | 1578 | WP_170078887.1 | phage portal protein | - |
| HG697_RS00950 (HG697_00955) | - | 147589..148737 (+) | 1149 | WP_170078889.1 | phage minor capsid protein | - |
| HG697_RS00955 (HG697_00960) | - | 148884..149447 (+) | 564 | WP_170078891.1 | phage scaffolding protein | - |
| HG697_RS00960 (HG697_00965) | - | 149466..150344 (+) | 879 | WP_003058535.1 | hypothetical protein | - |
| HG697_RS00965 (HG697_00970) | - | 150355..150591 (+) | 237 | WP_003058596.1 | hypothetical protein | - |
| HG697_RS00970 (HG697_00975) | - | 150635..151027 (+) | 393 | WP_003058548.1 | hypothetical protein | - |
| HG697_RS00975 (HG697_00980) | - | 151017..151343 (+) | 327 | WP_003058505.1 | putative minor capsid protein | - |
| HG697_RS00980 (HG697_00985) | - | 151343..151693 (+) | 351 | WP_003058592.1 | minor capsid protein | - |
| HG697_RS00985 (HG697_00990) | - | 151693..152100 (+) | 408 | WP_003058570.1 | minor capsid protein | - |
| HG697_RS00990 (HG697_00995) | - | 152105..152560 (+) | 456 | WP_003058598.1 | hypothetical protein | - |
| HG697_RS00995 (HG697_01000) | - | 152603..152983 (+) | 381 | WP_003058580.1 | hypothetical protein | - |
| HG697_RS01000 (HG697_01005) | - | 152983..153570 (+) | 588 | WP_003058588.1 | Gp15 family bacteriophage protein | - |
| HG697_RS01005 (HG697_01010) | - | 153590..157126 (+) | 3537 | WP_170078893.1 | tape measure protein | - |
| HG697_RS01010 (HG697_01015) | - | 157123..158625 (+) | 1503 | WP_170078895.1 | distal tail protein Dit | - |
| HG697_RS01015 (HG697_01020) | - | 158629..161553 (+) | 2925 | WP_165737299.1 | phage tail spike protein | - |
| HG697_RS01020 (HG697_01025) | - | 161565..163430 (+) | 1866 | WP_170078897.1 | DUF859 family phage minor structural protein | - |
| HG697_RS01025 (HG697_01030) | - | 163481..163909 (+) | 429 | WP_003058584.1 | DUF1366 domain-containing protein | - |
| HG697_RS01030 (HG697_01035) | - | 163875..164102 (+) | 228 | WP_037588167.1 | hypothetical protein | - |
| HG697_RS01035 (HG697_01040) | - | 164110..164577 (+) | 468 | WP_003058491.1 | phage holin family protein | - |
| HG697_RS01040 (HG697_01045) | - | 164570..164905 (+) | 336 | WP_003058565.1 | phage holin | - |
| HG697_RS01045 (HG697_01050) | - | 164907..166352 (+) | 1446 | WP_170078900.1 | peptidoglycan amidohydrolase family protein | - |
| HG697_RS01050 (HG697_01055) | - | 166490..166681 (+) | 192 | WP_003058494.1 | hypothetical protein | - |
| HG697_RS01055 (HG697_01060) | comGD | 166696..167088 (+) | 393 | WP_003058533.1 | competence type IV pilus minor pilin ComGD | - |
| HG697_RS01060 (HG697_01065) | comGE | 167096..167341 (+) | 246 | WP_003058569.1 | competence type IV pilus minor pilin ComGE | - |
| HG697_RS01065 (HG697_01070) | comGF | 167322..167762 (+) | 441 | WP_003058520.1 | competence type IV pilus minor pilin ComGF | - |
| HG697_RS01070 (HG697_01075) | comGG | 167785..168114 (+) | 330 | WP_003058539.1 | competence type IV pilus minor pilin ComGG | - |
| HG697_RS01075 (HG697_01080) | comYH | 168177..169130 (+) | 954 | WP_003060701.1 | class I SAM-dependent methyltransferase | Machinery gene |
Sequence
Protein
Download Length: 313 a.a. Molecular weight: 35224.31 Da Isoelectric Point: 7.0642
>NTDB_id=439811 HG697_RS00780 WP_003055265.1 127082..128023(+) (comGA/cglA) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A19]
MVQALARSILKEAEQIQAQDIYILPKEDQYELLIRVGDERRLVDVYRGDRMAHLISHFKFVAGMTVGEKRRCQVGSCDYD
IDGDTLLSLRLSSVGNYRGQESLVIRLLHHQQRSLHYWFDGLKTVARQIGGRGLYLFAGPVGSGKTTLMHQLIADYYQGA
QVISIEDPVEIKNHQALQLQVNDSIGMTYDNLIKLSLRHRPDILIIGEIRDSQTARAVIRASLTGVLVFSTVHAKSISGV
YARLLELGVTRAELDNCLALVAYQRLLNGGALIDSTQTEFEHYSPNQWNQKIDDLLAAGHLSPEQARFEKIIQ
MVQALARSILKEAEQIQAQDIYILPKEDQYELLIRVGDERRLVDVYRGDRMAHLISHFKFVAGMTVGEKRRCQVGSCDYD
IDGDTLLSLRLSSVGNYRGQESLVIRLLHHQQRSLHYWFDGLKTVARQIGGRGLYLFAGPVGSGKTTLMHQLIADYYQGA
QVISIEDPVEIKNHQALQLQVNDSIGMTYDNLIKLSLRHRPDILIIGEIRDSQTARAVIRASLTGVLVFSTVHAKSISGV
YARLLELGVTRAELDNCLALVAYQRLLNGGALIDSTQTEFEHYSPNQWNQKIDDLLAAGHLSPEQARFEKIIQ
Nucleotide
Download Length: 942 bp
>NTDB_id=439811 HG697_RS00780 WP_003055265.1 127082..128023(+) (comGA/cglA) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A19]
ATGGTACAAGCATTAGCAAGATCTATTTTGAAAGAAGCTGAGCAGATTCAAGCTCAAGATATCTATATTTTGCCAAAGGA
AGATCAGTATGAGCTATTGATAAGGGTAGGAGATGAAAGGAGATTGGTGGATGTTTATCGGGGCGATCGGATGGCTCATC
TTATTAGTCACTTTAAGTTCGTTGCAGGAATGACCGTTGGTGAGAAACGACGCTGTCAAGTCGGTTCTTGTGATTATGAT
ATCGATGGAGACACACTTTTGTCTCTACGCCTGTCTAGTGTTGGAAATTACCGTGGACAAGAGAGCCTAGTGATTCGGTT
ATTACATCATCAACAAAGAAGTTTACATTACTGGTTTGACGGACTGAAAACAGTTGCACGTCAGATTGGAGGCCGAGGAC
TCTATCTTTTTGCAGGTCCAGTCGGATCAGGCAAAACGACTTTGATGCACCAATTGATTGCTGATTATTATCAAGGAGCA
CAGGTCATTAGCATAGAAGATCCGGTGGAAATTAAAAATCATCAAGCGCTCCAATTACAAGTTAATGATAGTATTGGCAT
GACTTACGACAACTTGATCAAACTATCTTTACGGCATCGCCCTGATATTTTAATCATTGGTGAAATTCGAGACAGCCAGA
CAGCTAGAGCGGTTATTAGAGCAAGTTTAACAGGTGTCTTAGTATTTTCAACAGTTCATGCCAAAAGCATTTCTGGTGTT
TATGCCAGATTACTAGAACTAGGAGTGACAAGAGCAGAATTAGACAATTGTTTGGCTTTGGTTGCTTACCAACGATTGCT
TAATGGAGGAGCATTGATTGACTCAACTCAAACAGAATTTGAACACTACTCACCAAACCAATGGAATCAGAAAATTGATG
ACCTTCTTGCAGCGGGACATCTCAGTCCGGAGCAAGCAAGGTTTGAAAAAATTATCCAGTAA
ATGGTACAAGCATTAGCAAGATCTATTTTGAAAGAAGCTGAGCAGATTCAAGCTCAAGATATCTATATTTTGCCAAAGGA
AGATCAGTATGAGCTATTGATAAGGGTAGGAGATGAAAGGAGATTGGTGGATGTTTATCGGGGCGATCGGATGGCTCATC
TTATTAGTCACTTTAAGTTCGTTGCAGGAATGACCGTTGGTGAGAAACGACGCTGTCAAGTCGGTTCTTGTGATTATGAT
ATCGATGGAGACACACTTTTGTCTCTACGCCTGTCTAGTGTTGGAAATTACCGTGGACAAGAGAGCCTAGTGATTCGGTT
ATTACATCATCAACAAAGAAGTTTACATTACTGGTTTGACGGACTGAAAACAGTTGCACGTCAGATTGGAGGCCGAGGAC
TCTATCTTTTTGCAGGTCCAGTCGGATCAGGCAAAACGACTTTGATGCACCAATTGATTGCTGATTATTATCAAGGAGCA
CAGGTCATTAGCATAGAAGATCCGGTGGAAATTAAAAATCATCAAGCGCTCCAATTACAAGTTAATGATAGTATTGGCAT
GACTTACGACAACTTGATCAAACTATCTTTACGGCATCGCCCTGATATTTTAATCATTGGTGAAATTCGAGACAGCCAGA
CAGCTAGAGCGGTTATTAGAGCAAGTTTAACAGGTGTCTTAGTATTTTCAACAGTTCATGCCAAAAGCATTTCTGGTGTT
TATGCCAGATTACTAGAACTAGGAGTGACAAGAGCAGAATTAGACAATTGTTTGGCTTTGGTTGCTTACCAACGATTGCT
TAATGGAGGAGCATTGATTGACTCAACTCAAACAGAATTTGAACACTACTCACCAAACCAATGGAATCAGAAAATTGATG
ACCTTCTTGCAGCGGGACATCTCAGTCCGGAGCAAGCAAGGTTTGAAAAAATTATCCAGTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comGA/cglA | Streptococcus sobrinus strain NIDR 6715-7 |
62.701 |
99.361 |
0.623 |
| comYA | Streptococcus mutans UA140 |
61.736 |
99.361 |
0.613 |
| comYA | Streptococcus mutans UA159 |
61.736 |
99.361 |
0.613 |
| comYA | Streptococcus gordonii str. Challis substr. CH1 |
61.415 |
99.361 |
0.61 |
| comGA/cglA/cilD | Streptococcus mitis NCTC 12261 |
60.45 |
99.361 |
0.601 |
| comGA/cglA/cilD | Streptococcus pneumoniae Rx1 |
60.129 |
99.361 |
0.597 |
| comGA/cglA/cilD | Streptococcus pneumoniae D39 |
60.129 |
99.361 |
0.597 |
| comGA/cglA/cilD | Streptococcus pneumoniae R6 |
60.129 |
99.361 |
0.597 |
| comGA/cglA/cilD | Streptococcus pneumoniae TIGR4 |
60.129 |
99.361 |
0.597 |
| comGA | Lactococcus lactis subsp. cremoris KW2 |
52.09 |
99.361 |
0.518 |
| comGA | Latilactobacillus sakei subsp. sakei 23K |
38.908 |
93.61 |
0.364 |