Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   HB753_RS09765 Genome accession   NZ_CP050270
Coordinates   1988756..1990012 (+) Length   418 a.a.
NCBI ID   WP_002266115.1    Uniprot ID   -
Organism   Streptococcus mutans strain S4     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1983756..1995012
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HB753_RS09745 (HB753_09745) - 1984729..1985007 (-) 279 Protein_1883 transposase -
  HB753_RS09750 (HB753_09750) mutL 1985232..1987187 (+) 1956 WP_019804939.1 DNA mismatch repair endonuclease MutL -
  HB753_RS09755 (HB753_09755) ruvA 1987372..1987965 (+) 594 WP_002262395.1 Holliday junction branch migration protein RuvA -
  HB753_RS09760 (HB753_09760) - 1988047..1988607 (+) 561 WP_002271569.1 DNA-3-methyladenine glycosylase I -
  HB753_RS09765 (HB753_09765) cinA 1988756..1990012 (+) 1257 WP_002266115.1 competence/damage-inducible protein A Machinery gene
  HB753_RS09770 (HB753_09770) recA 1990052..1991203 (+) 1152 WP_002288707.1 recombinase RecA Machinery gene
  HB753_RS09775 (HB753_09775) spx 1991288..1991686 (+) 399 WP_002262391.1 transcriptional regulator Spx -
  HB753_RS09780 (HB753_09780) - 1991937..1992362 (+) 426 WP_002271571.1 hypothetical protein -
  HB753_RS09785 (HB753_09785) - 1992503..1992703 (+) 201 Protein_1891 hypothetical protein -
  HB753_RS09790 (HB753_09790) brsM 1992694..1993140 (-) 447 WP_002262388.1 bacteriocin genes regulator BrsM Regulator
  HB753_RS09795 (HB753_09795) brsR 1993153..1993587 (-) 435 WP_002266979.1 bacteriocin genes transcriptional regulator BrsR Regulator
  HB753_RS09800 (HB753_09800) - 1993755..1994024 (+) 270 WP_002262386.1 IreB family regulatory phosphoprotein -
  HB753_RS09805 (HB753_09805) ruvX 1994021..1994440 (+) 420 WP_002262385.1 Holliday junction resolvase RuvX -
  HB753_RS09810 (HB753_09810) - 1994521..1994820 (+) 300 WP_002262384.1 DUF1292 domain-containing protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45718.51 Da        Isoelectric Point: 6.2714

>NTDB_id=431081 HB753_RS09765 WP_002266115.1 1988756..1990012(+) (cinA) [Streptococcus mutans strain S4]
MKSEIIAVGTEILTGQIVNTNSQFLSEKFAELGIDVYFQTAVGDNEERLLSVLKIAKERSDLIVLCGGLGPTEDDLTKQT
LAKFLKRELVFDKTAQERLDEFFASRPTSMRTPNNECQAQIIAGSQPLSNKTGLAVGGLLEADGVTYVVLPGPPSELKPM
VNKELLPYLSKTSEKLYSRVLRFFGIGESHLVTLLHDLIAEQTDPTIAPYAKTGEVTIRLSTKAHRQKEADSKLDKLEKK
IITIDNLADYFYGYGEENSLPQVVFDLLKEKGKTITAAESLTAGLFQARLADFAGASDIFKGGFITYSIEEKARMLGIPF
EDLQLHGVVSAFTAEKMAERSRQLTQADLAVSLTGVAGPDSLEGQPAGTVFIGLSSSKRTMAIKVLIGGRSRSDVRYIAV
LHAFNLVRQTLLSHKNLV

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=431081 HB753_RS09765 WP_002266115.1 1988756..1990012(+) (cinA) [Streptococcus mutans strain S4]
ATGAAATCTGAGATCATTGCTGTTGGAACAGAAATTTTAACAGGACAAATTGTTAATACTAATAGTCAATTTTTATCAGA
AAAATTCGCAGAATTAGGAATTGATGTTTATTTTCAAACAGCAGTTGGTGATAATGAAGAACGCCTTTTATCTGTTTTGA
AAATTGCAAAGGAACGTAGTGATTTAATCGTACTTTGCGGTGGTTTGGGACCAACAGAAGATGATTTAACAAAACAAACC
TTAGCAAAATTTTTGAAAAGAGAATTGGTATTTGATAAAACAGCTCAAGAACGTCTAGATGAATTTTTTGCATCACGTCC
AACATCTATGCGCACGCCAAATAATGAATGTCAGGCGCAGATTATAGCAGGAAGTCAGCCTTTATCTAATAAAACAGGCT
TAGCAGTTGGGGGGCTTTTGGAAGCAGATGGAGTGACTTATGTTGTATTACCTGGTCCGCCTAGCGAATTGAAGCCTATG
GTTAACAAAGAGTTACTCCCTTATTTATCAAAAACTTCTGAGAAGCTTTATTCTCGTGTGTTACGCTTTTTTGGTATTGG
TGAGAGTCATCTAGTGACCTTGTTGCATGACTTAATAGCGGAGCAAACAGATCCCACAATTGCTCCTTATGCTAAGACAG
GCGAGGTAACAATACGTTTATCAACAAAAGCCCATAGGCAGAAAGAAGCAGATAGTAAGTTAGATAAGTTGGAAAAGAAA
ATTATAACTATTGATAACTTGGCTGATTATTTTTATGGTTATGGTGAAGAAAATTCATTACCACAGGTTGTATTTGATCT
GCTTAAGGAAAAGGGTAAAACGATTACAGCAGCTGAAAGTTTAACAGCAGGCCTTTTTCAGGCAAGATTAGCAGATTTTG
CAGGAGCATCTGATATCTTTAAGGGAGGTTTTATAACTTACAGTATAGAAGAGAAGGCTAGAATGCTAGGTATTCCCTTT
GAAGATCTCCAACTTCATGGGGTTGTTAGTGCTTTTACTGCTGAAAAGATGGCAGAGCGCTCCCGCCAGCTGACTCAAGC
AGATTTGGCTGTTTCTTTAACAGGAGTTGCAGGTCCGGATAGCTTAGAAGGTCAGCCGGCAGGGACAGTTTTTATCGGTT
TGTCAAGTTCCAAAAGAACAATGGCAATCAAAGTGTTAATTGGCGGACGCAGTCGGTCTGATGTGCGTTATATCGCTGTT
TTACATGCTTTTAATTTAGTACGTCAAACTTTATTATCTCATAAAAATTTAGTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-253)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(259-411)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

99.761

100

0.998
  cinA Streptococcus mitis SK321

72.249

100

0.722
  cinA Streptococcus mitis NCTC 12261

71.77

100

0.718
  cinA Streptococcus pneumoniae TIGR4

70.574

100

0.706
  cinA Streptococcus pneumoniae Rx1

70.335

100

0.703
  cinA Streptococcus pneumoniae R6

70.335

100

0.703
  cinA Streptococcus pneumoniae D39

70.096

100

0.701
  cinA Streptococcus suis isolate S10

55.474

98.325

0.545
  cinA Bacillus subtilis subsp. subtilis str. 168

45.763

98.804

0.452