Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HBA50_RS04940 Genome accession   NZ_CP050133
Coordinates   1005300..1005974 (+) Length   224 a.a.
NCBI ID   WP_045497279.1    Uniprot ID   A0A0F2CXX3
Organism   Streptococcus cristatus ATCC 51100     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1000300..1010974
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HBA50_RS04920 (HBA50_04920) - 1000721..1002085 (+) 1365 WP_045497270.1 RAMP superfamily CRISPR-associated protein -
  HBA50_RS04925 (HBA50_04925) csx19 1002057..1002602 (+) 546 WP_045497272.1 CRISPR-associated protein Csx19 -
  HBA50_RS04930 (HBA50_04930) - 1002592..1004388 (+) 1797 WP_166492634.1 RAMP superfamily CRISPR-associated protein -
  HBA50_RS04935 (HBA50_04935) - 1004742..1005179 (+) 438 WP_045497276.1 hypothetical protein -
  HBA50_RS04940 (HBA50_04940) ciaR 1005300..1005974 (+) 675 WP_045497279.1 response regulator transcription factor Regulator
  HBA50_RS04945 (HBA50_04945) ciaH 1005964..1007343 (+) 1380 WP_045497282.1 sensor histidine kinase KdpD Regulator
  HBA50_RS04950 (HBA50_04950) - 1007418..1007804 (+) 387 WP_005590267.1 VOC family protein -
  HBA50_RS04955 (HBA50_04955) - 1007894..1009291 (+) 1398 WP_045497284.1 polysaccharide deacetylase family protein -
  HBA50_RS04960 (HBA50_04960) - 1009374..1010462 (-) 1089 WP_306452456.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25315.00 Da        Isoelectric Point: 4.2907

>NTDB_id=430215 HBA50_RS04940 WP_045497279.1 1005300..1005974(+) (ciaR) [Streptococcus cristatus ATCC 51100]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNSTLVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTAFANNLQTLRSVGYILKNAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=430215 HBA50_RS04940 WP_045497279.1 1005300..1005974(+) (ciaR) [Streptococcus cristatus ATCC 51100]
ATGATTAAGATTCTATTAGTGGAGGATGACCTCGGTCTGTCAAATTCAGTATTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTCTTTGATGGCGAAGAAGGTTTATACGAAGCAGAAAGCGGTGTGTATGACCTGATTCTACTGGACTTGATGC
TTCCTGAAAAGGACGGCTTCCAAGTACTCAAAGAATTGCGTGAAAAAGGGGTGAGCACTCCTGTCCTCATTATGACTGCC
AAGGAAAGTATCGATGATAAAGGCCATGGTTTTGAGCTCGGTGCTGACGATTACTTGACTAAGCCTTTTTATCTGGAAGA
GCTGAAGATGCGGATTCAAGCCTTGCTCAAACGATCTGGTAAGTTTAATGAAAATACCCTTTCCTATGGTGATGTGACGG
TCAATCTTTCGACCAATTCGACCTTGGTAGATGGAAAGGAAGTTGAGTTGCTGGGTAAAGAGTTTGATCTGTTGGTCTAC
TTCCTTCAGAATCAAAATGTCATTTTGCCCAAGACTCAAATCTTCGACCGTTTGTGGGGCTTTGACAGCGATACGACCAT
TTCTGTGGTGGAGGTCTATGTATCTAAGATTCGGAAAAAATTGAAAGGAACGGCTTTTGCGAATAATCTTCAAACCCTTC
GCAGTGTCGGTTACATTTTAAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2CXX3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.179

100

0.902
  ciaR Streptococcus pneumoniae D39

90.179

100

0.902
  ciaR Streptococcus pneumoniae R6

90.179

100

0.902
  ciaR Streptococcus pneumoniae TIGR4

90.179

100

0.902
  ciaR Streptococcus mutans UA159

88.789

99.554

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.381

100

0.397
  vicR Streptococcus mutans UA159

35.897

100

0.375
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366
  micA Streptococcus pneumoniae Cp1015

34.764

100

0.362