Detailed information NTG0399453

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: GJE16_RS10655
• Genome accession: NZ_CP045931
• Coordinates: 2085418..2086170 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866058.1
• Uniprot ID: A0AAX3HG98
• Organism: Streptococcus pneumoniae strain AUSMDU00010538
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2080418..2091170

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GJE16_RS11370 (GJE16_10635)	-	2082852..2084505 (-)	1654	Protein_2048	YhgE/Pip family protein	-
GJE16_RS10640 (GJE16_10640)	-	2084633..2085175 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
GJE16_RS10655 (GJE16_10655)	comE	2085418..2086170 (-)	753	WP_000866058.1	competence system response regulator transcription factor ComE	Regulator
GJE16_RS10660 (GJE16_10660)	comD/comD1	2086167..2087492 (-)	1326	WP_001813347.1	competence system sensor histidine kinase ComD	Regulator
GJE16_RS10665 (GJE16_10665)	comC/comC1	2087513..2087638 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
GJE16_RS10675 (GJE16_10675)	rlmH	2087921..2088400 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
GJE16_RS10680 (GJE16_10680)	htrA	2088583..2089764 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
GJE16_RS10685 (GJE16_10685)	spo0J	2089822..2090580 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29992.33 Da
• Isoelectric Point: 6.5073

>NTDB_id=399453 GJE16_RS10655 WP_000866058.1 2085418..2086170(-) (comE) [Streptococcus pneumoniae strain AUSMDU00010538]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=399453 GJE16_RS10655 WP_000866058.1 2085418..2086170(-) (comE) [Streptococcus pneumoniae strain AUSMDU00010538]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGTTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98.8	100	0.988
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408