Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   F5989_RS06840 Genome accession   NZ_CP044221
Coordinates   1378561..1379817 (+) Length   418 a.a.
NCBI ID   WP_002270966.1    Uniprot ID   -
Organism   Streptococcus mutans strain NCH105     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1373561..1384817
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  F5989_RS06820 (F5989_06945) - 1374537..1374815 (-) 279 Protein_1281 transposase -
  F5989_RS06825 (F5989_06950) mutL 1375040..1376995 (+) 1956 WP_002266974.1 DNA mismatch repair endonuclease MutL -
  F5989_RS06830 (F5989_06955) ruvA 1377177..1377770 (+) 594 WP_002266975.1 Holliday junction branch migration protein RuvA -
  F5989_RS06835 (F5989_06960) - 1377852..1378412 (+) 561 WP_002266114.1 DNA-3-methyladenine glycosylase I -
  F5989_RS06840 (F5989_06965) cinA 1378561..1379817 (+) 1257 WP_002270966.1 competence/damage-inducible protein A Machinery gene
  F5989_RS06845 (F5989_06970) recA 1379857..1381008 (+) 1152 WP_002262392.1 recombinase RecA Machinery gene
  F5989_RS06850 (F5989_06975) spx 1381093..1381491 (+) 399 WP_002262391.1 transcriptional regulator Spx -
  F5989_RS06855 (F5989_06980) - 1381742..1382167 (+) 426 WP_002262390.1 hypothetical protein -
  F5989_RS06860 (F5989_06985) - 1382294..1382506 (+) 213 WP_002262389.1 hypothetical protein -
  F5989_RS06865 (F5989_06990) brsM 1382497..1382943 (-) 447 WP_002262388.1 bacteriocin genes regulator BrsM Regulator
  F5989_RS06870 (F5989_06995) brsR 1382956..1383390 (-) 435 WP_156294876.1 bacteriocin genes transcriptional regulator BrsR Regulator
  F5989_RS06875 (F5989_07000) - 1383558..1383827 (+) 270 WP_002262386.1 IreB family regulatory phosphoprotein -
  F5989_RS06880 (F5989_07005) ruvX 1383824..1384243 (+) 420 WP_002262385.1 Holliday junction resolvase RuvX -
  F5989_RS06885 (F5989_07010) - 1384324..1384623 (+) 300 WP_002262384.1 DUF1292 domain-containing protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45704.48 Da        Isoelectric Point: 6.2714

>NTDB_id=388844 F5989_RS06840 WP_002270966.1 1378561..1379817(+) (cinA) [Streptococcus mutans strain NCH105]
MKSEIIAVGTEILTGQIVNTNSQFLSEKFAELGIDVYFQTAVGDNEERLLSVLKIAKERSDLIVLCGGLGPTEDDLTKQT
LAKFLKRELVFDKTAQERLDEFFASRPTSMRTPNNECQAQIIAGSQPLSNKTGLAVGGLLEADGVTYVVLPGPPSELKPM
VNKELLPYLSKTSEKLYSRVLRFFGIGESHLVTLLHDLIAEQTDPTIAPYAKTGEVTIRLSTKAHRQKEADSKLDKLEKK
IVTIDNLADYFYGYGEENSLPQVVFDLLKEKGKTITAAESLTAGLFQARLADFAGASDIFKGGFITYSIEEKARMLGIPF
EDLQLHGVVSAFTAEKMAERSRQLTQADLAVSLTGVAGPDSLEGQPAGTVFIGLSSSKRTMAIKVLIGGRSRSDVRYIAV
LHAFNLVRQTLLSHKNLV

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=388844 F5989_RS06840 WP_002270966.1 1378561..1379817(+) (cinA) [Streptococcus mutans strain NCH105]
ATGAAATCTGAGATCATTGCTGTTGGAACAGAAATTTTAACAGGACAAATTGTTAATACTAATAGTCAATTTTTATCAGA
AAAATTCGCAGAATTAGGAATTGATGTTTATTTTCAAACAGCAGTTGGTGATAATGAAGAACGCCTTTTATCTGTTTTGA
AAATTGCAAAGGAACGTAGTGATTTAATTGTACTTTGCGGTGGTTTGGGACCAACAGAAGATGATTTAACAAAACAAACC
CTAGCAAAATTTTTGAAAAGAGAATTGGTATTTGATAAAACAGCTCAAGAACGTCTAGATGAATTTTTTGCATCACGTCC
AACATCTATGCGCACACCAAATAATGAATGTCAGGCGCAGATTATAGCAGGAAGTCAGCCTTTATCTAATAAAACAGGCT
TAGCAGTTGGGGGGCTTTTGGAGGCAGATGGAGTGACTTATGTTGTATTACCTGGTCCGCCTAGCGAATTGAAGCCTATG
GTTAACAAAGAGTTACTCCCTTATTTATCAAAAACTTCTGAGAAGCTTTATTCTCGTGTGTTACGCTTTTTTGGTATTGG
TGAGAGTCATCTAGTGACCTTGTTGCATGACTTAATAGCGGAGCAAACAGATCCCACAATTGCTCCTTATGCTAAGACAG
GCGAGGTAACAATACGTTTATCAACAAAAGCCCATAGGCAGAAAGAAGCAGATAGTAAGTTAGATAAGTTGGAAAAGAAA
ATTGTAACTATTGATAACTTGGCTGATTATTTTTATGGTTATGGTGAAGAAAATTCATTACCACAGGTTGTATTTGATCT
GCTTAAGGAAAAGGGTAAAACGATTACAGCAGCTGAAAGTTTAACAGCAGGCCTTTTTCAGGCAAGATTAGCAGATTTTG
CAGGAGCATCTGATATCTTTAAGGGAGGTTTTATAACTTACAGTATAGAAGAGAAGGCTAGAATGCTAGGTATTCCCTTT
GAAGATCTCCAACTTCATGGGGTTGTTAGTGCTTTTACTGCTGAAAAGATGGCAGAGCGCTCCCGCCAGCTGACTCAAGC
AGATTTGGCTGTTTCTTTAACAGGAGTTGCAGGTCCGGATAGCTTAGAAGGTCAGCCGGCAGGGACAGTTTTTATCGGTT
TGTCAAGTTCCAAAAGAACAATGGCAATCAAAGTGTTAATTGGCGGACGCAGTCGGTCTGATGTGCGTTATATCGCTGTT
TTACATGCTTTTAATTTAGTACGTCAAACTTTATTATCTCATAAAAATTTAGTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-253)

Competence-damaged protein (CinA)

(259-411)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

99.522

100

0.995
  cinA Streptococcus mitis SK321

72.249

100

0.722
  cinA Streptococcus mitis NCTC 12261

71.77

100

0.718
  cinA Streptococcus pneumoniae TIGR4

70.574

100

0.706
  cinA Streptococcus pneumoniae Rx1

70.335

100

0.703
  cinA Streptococcus pneumoniae R6

70.335

100

0.703
  cinA Streptococcus pneumoniae D39

70.096

100

0.701
  cinA Streptococcus suis isolate S10

55.474

98.325

0.545
  cinA Bacillus subtilis subsp. subtilis str. 168

46.005

98.804

0.455

Multiple sequence alignment