Detailed information NTG0377700

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: FGL73_RS05040
• Genome accession: NZ_CP042408
• Coordinates: 1091642..1092334 (-)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis strain CBA3619
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1086642..1097334

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL73_RS05025 (FGL73_05025)	-	1088261..1088602 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
FGL73_RS05030 (FGL73_05030)	-	1088734..1089975 (-)	1242	WP_038601519.1	ammonium transporter	-
FGL73_RS05035 (FGL73_05035)	covS	1090158..1091633 (-)	1476	WP_146978148.1	HAMP domain-containing histidine kinase	Regulator
FGL73_RS05040 (FGL73_05040)	covR	1091642..1092334 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
FGL73_RS05045 (FGL73_05045)	-	1092490..1093020 (-)	531	WP_058205814.1	DUF177 domain-containing protein	-
FGL73_RS05050 (FGL73_05050)	-	1093151..1093396 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
FGL73_RS05055 (FGL73_05055)	-	1093552..1094016 (-)	465	WP_029344120.1	hypothetical protein	-
FGL73_RS05060 (FGL73_05060)	-	1094098..1094460 (-)	363	WP_038601523.1	TIGR02328 family protein	-
FGL73_RS05065 (FGL73_05065)	-	1094676..1095518 (-)	843	WP_098393427.1	metallophosphoesterase	-
FGL73_RS05070 (FGL73_05070)	-	1095748..1096341 (-)	594	WP_038601525.1	TMEM175 family protein	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=377700 FGL73_RS05040 WP_003130756.1 1091642..1092334(-) (covR) [Lactococcus lactis strain CBA3619]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=377700 FGL73_RS05040 WP_003130756.1 1091642..1092334(-) (covR) [Lactococcus lactis strain CBA3619]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCACGATTCGTCTCATTAGAATTGGAGCATGAAGG
CTATGCGACTGAGATTAAAGATAATGGACGCTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCTCGTCGTTTACGCAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGAGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCCAT
CGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAACATGGTCACGCCGTTGAGCGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACAAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTTCTTTTGACGTTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAGGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361