Detailed information NTG0355636

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: E5Q10_RS11785
• Genome accession: NZ_CP038808
• Coordinates: 475050..475637 (-)
• Length: 195 a.a.
• NCBI ID: WP_001856103.1
• Uniprot ID: A7XHI1
• Organism: Streptococcus pneumoniae strain R6CIB17
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 470050..480637

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E5Q10_RS02485 (E5Q10_02485)	-	470514..471854 (+)	1341	WP_001017622.1	sensor histidine kinase	-
E5Q10_RS02490 (E5Q10_02490)	blpC	471896..472051 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
E5Q10_RS02495 (E5Q10_02495)	-	472108..473469 (-)	1362	Protein_465	bacteriocin secretion accessory protein	-
E5Q10_RS02500 (E5Q10_02500)	comA/nlmT	473480..475156 (-)	1677	WP_306423909.1	peptide cleavage/export ABC transporter	Regulator
E5Q10_RS11785	comA/nlmT	475050..475637 (-)	588	WP_001856103.1	cysteine peptidase family C39 domain-containing protein	Regulator
E5Q10_RS02505 (E5Q10_02505)	-	475927..476160 (+)	234	WP_001093273.1	hypothetical protein	-
E5Q10_RS02510 (E5Q10_02510)	-	476192..476881 (+)	690	WP_000760523.1	CPBP family intramembrane glutamic endopeptidase	-
E5Q10_RS02515 (E5Q10_02515)	blpZ	476923..477156 (+)	234	WP_000276498.1	immunity protein BlpZ	-
E5Q10_RS02525 (E5Q10_02525)	-	477307..477918 (+)	612	WP_000394036.1	CPBP family intramembrane glutamic endopeptidase	-
E5Q10_RS02530 (E5Q10_02530)	ccrZ	478079..478873 (+)	795	WP_000363002.1	cell cycle regulator CcrZ	-
E5Q10_RS02535 (E5Q10_02535)	trmB	478870..479505 (+)	636	WP_001266083.1	tRNA (guanosine(46)-N7)-methyltransferase TrmB	-
E5Q10_RS02540 (E5Q10_02540)	rimP	479631..480110 (+)	480	WP_001810863.1	ribosome maturation factor RimP	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22352.81 Da
• Isoelectric Point: 9.7004

>NTDB_id=355636 E5Q10_RS11785 WP_001856103.1 475050..475637(-) (comA/nlmT) [Streptococcus pneumoniae strain R6CIB17]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQAYKTLFDMSDV
PYPFIVHVNKEGKFQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=355636 E5Q10_RS11785 WP_001856103.1 475050..475637(-) (comA/nlmT) [Streptococcus pneumoniae strain R6CIB17]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCATATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAATTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A7XHI1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	58.791	93.333	0.549
comA	Streptococcus mitis NCTC 12261	53.804	94.359	0.508
comA	Streptococcus mitis SK321	53.261	94.359	0.503
comA	Streptococcus pneumoniae Rx1	52.717	94.359	0.497
comA	Streptococcus pneumoniae D39	52.717	94.359	0.497
comA	Streptococcus pneumoniae R6	52.717	94.359	0.497
comA	Streptococcus pneumoniae TIGR4	52.717	94.359	0.497
comA	Streptococcus gordonii str. Challis substr. CH1	51.63	94.359	0.487