Detailed information NTG0352666

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ES276_RS10750
• Genome accession: NZ_CP038252
• Coordinates: 2134487..2135224 (-)
• Length: 245 a.a.
• NCBI ID: WP_000866067.1
• Uniprot ID: A0A0T9ZVK7
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2133531..2134484	2134487..2135224	flank	3

Gene organization within MGE regions

Location: 2133531..2135224

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS10745 (ES276_11420)	-	2133531..2134484 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
ES276_RS10750 (ES276_11425)	comE	2134487..2135224 (-)	738	WP_000866067.1	competence system response regulator transcription factor ComE	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 29276.43 Da
• Isoelectric Point: 6.1046

>NTDB_id=352666 ES276_RS10750 WP_000866067.1 2134487..2135224(-) (comE) [Streptococcus pneumoniae strain TVO_1901936]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
TQISS

Nucleotide

• Length: 738 bp

>NTDB_id=352666 ES276_RS10750 WP_000866067.1 2134487..2135224(-) (comE) [Streptococcus pneumoniae strain TVO_1901936]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
ACCCAAATTTCAAGTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-243)

3D structure

• AlphaFold DB: A0A0T9ZVK7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.177	99.184	0.984
comE	Streptococcus pneumoniae D39	99.177	99.184	0.984
comE	Streptococcus pneumoniae R6	99.177	99.184	0.984
comE	Streptococcus pneumoniae TIGR4	99.177	99.184	0.984
comE	Streptococcus mitis SK321	98.354	99.184	0.976
comE	Streptococcus mitis NCTC 12261	97.531	99.184	0.967
comE	Streptococcus infantis strain Atu-4	90.947	99.184	0.902
comE/comE2	Streptococcus gordonii strain NCTC7865	62.551	99.184	0.62
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.551	99.184	0.62
comE/blpR	Streptococcus mutans UA159	41.463	100	0.416