Detailed information NTG0352666

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ES276_RS10750
• Genome accession: NZ_CP038252
• Coordinates: 2134487..2135224 (-)
• Length: 245 a.a.
• NCBI ID: WP_000866067.1
• Uniprot ID: A0A0T9ZVK7
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2129487..2140224

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS10725	-	2130661..2132263 (-)	1603	Protein_2104	YhgE/Pip family protein	-
ES276_RS10730 (ES276_11405)	-	2132442..2132984 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
ES276_RS10745 (ES276_11420)	-	2133531..2134484 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
ES276_RS10750 (ES276_11425)	comE	2134487..2135224 (-)	738	WP_000866067.1	competence system response regulator transcription factor ComE	Regulator
ES276_RS10755 (ES276_11430)	comD	2135221..2136547 (-)	1327	Protein_2108	competence system sensor histidine kinase ComD	-
ES276_RS10760 (ES276_11435)	comC/comC2	2136568..2136693 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
ES276_RS10770 (ES276_11445)	rlmH	2136975..2137454 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ES276_RS10775 (ES276_11450)	htrA	2137637..2138818 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
ES276_RS10780 (ES276_11455)	spo0J	2138876..2139634 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 29276.43 Da
• Isoelectric Point: 6.1046

>NTDB_id=352666 ES276_RS10750 WP_000866067.1 2134487..2135224(-) (comE) [Streptococcus pneumoniae strain TVO_1901936]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
TQISS

Nucleotide

• Length: 738 bp

>NTDB_id=352666 ES276_RS10750 WP_000866067.1 2134487..2135224(-) (comE) [Streptococcus pneumoniae strain TVO_1901936]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGTAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
ACCCAAATTTCAAGTTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-243)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.177	99.184	0.984
comE	Streptococcus pneumoniae D39	99.177	99.184	0.984
comE	Streptococcus pneumoniae R6	99.177	99.184	0.984
comE	Streptococcus pneumoniae TIGR4	99.177	99.184	0.984
comE	Streptococcus mitis SK321	98.354	99.184	0.976
comE	Streptococcus mitis NCTC 12261	97.531	99.184	0.967
comE	Streptococcus infantis strain Atu-4	90.947	99.184	0.902
comE/comE2	Streptococcus gordonii strain NCTC7865	62.551	99.184	0.62
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.551	99.184	0.62
comE/blpR	Streptococcus mutans UA159	41.463	100	0.416