Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT57_RS08920 Genome accession   NZ_CP035442
Coordinates   1749328..1750599 (-) Length   423 a.a.
NCBI ID   WP_136048584.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm25     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1744328..1755599
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT57_RS08895 (ETT57_08885) - 1746298..1746603 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT57_RS08900 (ETT57_08890) ruvX 1746615..1747034 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT57_RS08905 (ETT57_08895) - 1747031..1747300 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT57_RS08910 (ETT57_08900) spx 1747414..1747812 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT57_RS08915 (ETT57_08905) recA 1748103..1749239 (-) 1137 WP_023612576.1 recombinase RecA Machinery gene
  ETT57_RS08920 (ETT57_08910) cinA 1749328..1750599 (-) 1272 WP_136048584.1 competence/damage-inducible protein A Machinery gene
  ETT57_RS08925 (ETT57_08915) - 1750668..1751228 (-) 561 Protein_1656 DNA-3-methyladenine glycosylase I -
  ETT57_RS08930 (ETT57_08920) ruvA 1751238..1751834 (-) 597 WP_053308677.1 Holliday junction branch migration protein RuvA -
  ETT57_RS08935 (ETT57_08925) - 1751836..1753056 (-) 1221 WP_053308678.1 MFS transporter -
  ETT57_RS08940 (ETT57_08930) mutL 1753067..1755049 (-) 1983 WP_053308679.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46076.83 Da        Isoelectric Point: 4.7760

>NTDB_id=341829 ETT57_RS08920 WP_136048584.1 1749328..1750599(-) (cinA) [Streptococcus pyogenes strain emm25]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELIPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEEMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341829 ETT57_RS08920 WP_136048584.1 1749328..1750599(-) (cinA) [Streptococcus pyogenes strain emm25]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTAATACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGAGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGCGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.89

98.818

0.463

Multiple sequence alignment