Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT59_RS08530 Genome accession   NZ_CP035440
Coordinates   1706870..1708141 (-) Length   423 a.a.
NCBI ID   WP_032459984.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm124     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1701870..1713141
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT59_RS08505 (ETT59_08500) - 1703840..1704145 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT59_RS08510 (ETT59_08505) ruvX 1704157..1704576 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT59_RS08515 (ETT59_08510) - 1704573..1704842 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT59_RS08520 (ETT59_08515) spx 1704956..1705354 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT59_RS08525 (ETT59_08520) recA 1705645..1706781 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  ETT59_RS08530 (ETT59_08525) cinA 1706870..1708141 (-) 1272 WP_032459984.1 competence/damage-inducible protein A Machinery gene
  ETT59_RS08535 (ETT59_08530) - 1708210..1708770 (-) 561 WP_023611248.1 DNA-3-methyladenine glycosylase I -
  ETT59_RS08540 (ETT59_08535) ruvA 1708780..1709376 (-) 597 WP_136305971.1 Holliday junction branch migration protein RuvA -
  ETT59_RS08545 (ETT59_08540) - 1709378..1710598 (-) 1221 WP_002991361.1 MFS transporter -
  ETT59_RS08550 (ETT59_08545) mutL 1710609..1712591 (-) 1983 WP_136267866.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 46018.75 Da        Isoelectric Point: 4.8322

>NTDB_id=341720 ETT59_RS08530 WP_032459984.1 1706870..1708141(-) (cinA) [Streptococcus pyogenes strain emm124]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341720 ETT59_RS08530 WP_032459984.1 1706870..1708141(-) (cinA) [Streptococcus pyogenes strain emm124]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.976

100

0.7
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.89

98.818

0.463

Multiple sequence alignment