Detailed information NTG0341667

Bioinformatically predicted

Overview

• Name: cinA
• Type: Machinery gene
• Locus tag: ETT60_RS08735
• Genome accession: NZ_CP035439
• Coordinates: 1726617..1727888 (-)
• Length: 423 a.a.
• NCBI ID: WP_030126182.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm77
• Function: require for competence (predicted from homology) Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	1714575..1733578	1726617..1727888	within	0

Gene organization within MGE regions

Location: 1714575..1733578

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT60_RS08670 (ETT60_08660)	-	1714575..1714814 (-)	240	WP_229293985.1	helix-turn-helix domain-containing protein	-
ETT60_RS08675 (ETT60_08665)	-	1715092..1715949 (+)	858	WP_129284222.1	VOC family protein	-
ETT60_RS08680 (ETT60_08670)	yaaA	1715991..1716722 (+)	732	WP_012561068.1	peroxide stress protein YaaA	-
ETT60_RS08685 (ETT60_08675)	nrdG	1716896..1717510 (-)	615	WP_002982219.1	anaerobic ribonucleoside-triphosphate reductase activating protein	-
ETT60_RS08690 (ETT60_08680)	-	1717510..1718019 (-)	510	WP_129284223.1	GNAT family N-acetyltransferase	-
ETT60_RS08695 (ETT60_08685)	-	1718028..1718963 (-)	936	WP_129284224.1	Gfo/Idh/MocA family protein	-
ETT60_RS09220	-	1718992..1719138 (-)	147	WP_023610752.1	hypothetical protein	-
ETT60_RS08700 (ETT60_08690)	nrdD	1719320..1721518 (-)	2199	WP_002992831.1	anaerobic ribonucleoside-triphosphate reductase	-
ETT60_RS08705 (ETT60_08695)	-	1721615..1723174 (-)	1560	WP_115354331.1	DUF2079 domain-containing protein	-
ETT60_RS08710 (ETT60_08700)	-	1723587..1723892 (-)	306	WP_002982199.1	DUF1292 domain-containing protein	-
ETT60_RS08715 (ETT60_08705)	ruvX	1723904..1724323 (-)	420	WP_002982196.1	Holliday junction resolvase RuvX	-
ETT60_RS08720 (ETT60_08710)	-	1724320..1724589 (-)	270	WP_002982194.1	IreB family regulatory phosphoprotein	-
ETT60_RS08725 (ETT60_08715)	spx	1724703..1725101 (-)	399	WP_002982188.1	transcriptional regulator Spx	-
ETT60_RS08730 (ETT60_08720)	recA	1725392..1726528 (-)	1137	WP_002992179.1	recombinase RecA	Machinery gene
ETT60_RS08735 (ETT60_08725)	cinA	1726617..1727888 (-)	1272	WP_030126182.1	competence/damage-inducible protein A	Machinery gene
ETT60_RS08740 (ETT60_08730)	-	1727957..1728517 (-)	561	WP_063812052.1	DNA-3-methyladenine glycosylase I	-
ETT60_RS08745 (ETT60_08735)	ruvA	1728527..1729123 (-)	597	WP_011285268.1	Holliday junction branch migration protein RuvA	-
ETT60_RS08750 (ETT60_08740)	-	1729125..1730345 (-)	1221	WP_136114721.1	MFS transporter	-
ETT60_RS08755 (ETT60_08745)	mutL	1730356..1732338 (-)	1983	WP_032467454.1	DNA mismatch repair endonuclease MutL	-

Sequence

Protein

• Length: 423 a.a.
• Molecular weight: 45989.79 Da
• Isoelectric Point: 4.9844

>NTDB_id=341667 ETT60_RS08735 WP_030126182.1 1726617..1727888(-) (cinA) [Streptococcus pyogenes strain emm77]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDKQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide

• Length: 1272 bp

>NTDB_id=341667 ETT60_RS08735 WP_030126182.1 1726617..1727888(-) (cinA) [Streptococcus pyogenes strain emm77]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATAAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

• Competence-damaged protein (CinA) (263-416)

• Damage-inducible protein CinA KH domain (CinA_KH) (178-243)

• Probable molybdopterin binding domain (MoCF_biosynth) (5-170)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cinA	Streptococcus mutans UA159	69.976	100	0.7
cinA	Streptococcus mitis SK321	70.024	98.582	0.69
cinA	Streptococcus mitis NCTC 12261	69.544	98.582	0.686
cinA	Streptococcus pneumoniae TIGR4	68.585	98.582	0.676
cinA	Streptococcus pneumoniae Rx1	68.585	98.582	0.676
cinA	Streptococcus pneumoniae R6	68.585	98.582	0.676
cinA	Streptococcus pneumoniae D39	68.345	98.582	0.674
cinA	Streptococcus suis isolate S10	52.885	98.345	0.52
cinA	Bacillus subtilis subsp. subtilis str. 168	46.651	98.818	0.461