Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT62_RS08705 Genome accession   NZ_CP035437
Coordinates   1731019..1732290 (-) Length   423 a.a.
NCBI ID   WP_136109421.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm78.3     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1718974..1759001 1731019..1732290 within 0


Gene organization within MGE regions


Location: 1718974..1759001
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT62_RS08640 (ETT62_08630) - 1718974..1719257 (-) 284 Protein_1594 winged helix-turn-helix transcriptional regulator -
  ETT62_RS08645 (ETT62_08635) - 1719493..1720350 (+) 858 WP_115354328.1 VOC family protein -
  ETT62_RS08650 (ETT62_08640) yaaA 1720392..1721123 (+) 732 WP_063631416.1 peroxide stress protein YaaA -
  ETT62_RS08655 (ETT62_08645) nrdG 1721297..1721911 (-) 615 WP_021775544.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  ETT62_RS08660 (ETT62_08650) - 1721926..1722420 (-) 495 WP_011055085.1 GNAT family N-acetyltransferase -
  ETT62_RS08665 (ETT62_08655) - 1722429..1723364 (-) 936 WP_009880789.1 Gfo/Idh/MocA family protein -
  ETT62_RS09155 - 1723393..1723539 (-) 147 WP_168694185.1 hypothetical protein -
  ETT62_RS08670 (ETT62_08660) nrdD 1723721..1725919 (-) 2199 WP_002982204.1 anaerobic ribonucleoside-triphosphate reductase -
  ETT62_RS08675 (ETT62_08665) - 1726016..1727575 (-) 1560 WP_111703695.1 DUF2079 domain-containing protein -
  ETT62_RS08680 (ETT62_08670) - 1727989..1728294 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT62_RS08685 (ETT62_08675) ruvX 1728306..1728725 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT62_RS08690 (ETT62_08680) - 1728722..1728991 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT62_RS08695 (ETT62_08685) spx 1729105..1729503 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT62_RS08700 (ETT62_08690) recA 1729794..1730930 (-) 1137 WP_136120903.1 recombinase RecA Machinery gene
  ETT62_RS08705 (ETT62_08695) cinA 1731019..1732290 (-) 1272 WP_136109421.1 competence/damage-inducible protein A Machinery gene
  ETT62_RS08710 (ETT62_08700) - 1732359..1732919 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  ETT62_RS08715 (ETT62_08705) ruvA 1732929..1733525 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA -
  ETT62_RS08720 (ETT62_08710) - 1733527..1734747 (-) 1221 WP_136120904.1 MFS transporter -
  ETT62_RS08725 (ETT62_08715) mutL 1734758..1736740 (-) 1983 WP_002991363.1 DNA mismatch repair endonuclease MutL -
  ETT62_RS08730 (ETT62_08720) mutS 1736869..1739424 (-) 2556 WP_136120905.1 DNA mismatch repair protein MutS -
  ETT62_RS09350 (ETT62_08725) - 1739411..1739617 (-) 207 WP_010922774.1 YlbF family regulator -
  ETT62_RS08740 (ETT62_08730) argR 1739760..1740197 (-) 438 WP_002982171.1 arginine repressor -
  ETT62_RS08745 (ETT62_08735) argS 1740488..1742179 (+) 1692 WP_129304966.1 arginine--tRNA ligase -
  ETT62_RS08750 (ETT62_08740) - 1742321..1742572 (+) 252 WP_227878189.1 bacteriocin immunity protein -
  ETT62_RS08755 (ETT62_08745) - 1742599..1743471 (-) 873 WP_002982164.1 YitT family protein -
  ETT62_RS08760 (ETT62_08750) - 1743514..1744392 (-) 879 WP_023610708.1 YitT family protein -
  ETT62_RS08765 (ETT62_08755) - 1744412..1745353 (-) 942 WP_002991375.1 YitT family protein -
  ETT62_RS08770 (ETT62_08760) aspS 1745346..1747094 (-) 1749 WP_021775564.1 aspartate--tRNA ligase -
  ETT62_RS08775 (ETT62_08765) hisS 1747432..1748712 (-) 1281 WP_136095217.1 histidine--tRNA ligase -
  ETT62_RS08780 (ETT62_08770) rpmF 1748932..1749114 (+) 183 WP_000290414.1 50S ribosomal protein L32 -
  ETT62_RS08785 (ETT62_08775) rpmG 1749130..1749279 (+) 150 WP_002982147.1 50S ribosomal protein L33 -
  ETT62_RS09355 (ETT62_08780) - 1749319..1749543 (-) 225 WP_080262104.1 FanG protein -
  ETT62_RS08795 (ETT62_08785) - 1749572..1750186 (+) 615 WP_002995289.1 CadD family cadmium resistance transporter -
  ETT62_RS08800 (ETT62_08790) - 1750280..1751509 (-) 1230 WP_136120906.1 IS110 family transposase -
  ETT62_RS08805 (ETT62_08795) cadX 1751813..1752151 (+) 339 WP_000711078.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  ETT62_RS08810 (ETT62_08800) - 1752202..1753617 (+) 1416 WP_175393064.1 helix-turn-helix domain-containing protein -
  ETT62_RS08815 (ETT62_08805) - 1753929..1754381 (+) 453 WP_110002647.1 RNA polymerase sigma factor -
  ETT62_RS08820 (ETT62_08810) - 1754574..1754894 (+) 321 WP_136120908.1 hypothetical protein -
  ETT62_RS08825 (ETT62_08815) - 1754894..1755994 (+) 1101 WP_111685319.1 ABC transporter ATP-binding protein -
  ETT62_RS08830 (ETT62_08820) - 1755991..1756596 (+) 606 WP_136120909.1 hypothetical protein -
  ETT62_RS08835 (ETT62_08825) - 1756804..1757406 (+) 603 WP_111685323.1 replication protein -
  ETT62_RS08840 (ETT62_08830) - 1757399..1757647 (+) 249 WP_111685393.1 hypothetical protein -
  ETT62_RS08845 (ETT62_08835) - 1757736..1759001 (+) 1266 WP_111685325.1 site-specific integrase -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45946.73 Da        Isoelectric Point: 4.8970

>NTDB_id=341558 ETT62_RS08705 WP_136109421.1 1731019..1732290(-) (cinA) [Streptococcus pyogenes strain emm78.3]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTVVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAGGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341558 ETT62_RS08705 WP_136109421.1 1731019..1732290(-) (cinA) [Streptococcus pyogenes strain emm78.3]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGTTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGGGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.345

98.582

0.674
  cinA Streptococcus pneumoniae Rx1

68.345

98.582

0.674
  cinA Streptococcus pneumoniae R6

68.345

98.582

0.674
  cinA Streptococcus pneumoniae D39

68.106

98.582

0.671
  cinA Streptococcus suis isolate S10

52.506

99.054

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment