Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT64_RS08815 Genome accession   NZ_CP035435
Coordinates   1708400..1709671 (-) Length   423 a.a.
NCBI ID   WP_136021357.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm64.3     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1703400..1714671
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT64_RS08790 (ETT64_08785) - 1705370..1705675 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT64_RS08795 (ETT64_08790) ruvX 1705687..1706106 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT64_RS08800 (ETT64_08795) - 1706103..1706372 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT64_RS08805 (ETT64_08800) spx 1706486..1706884 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT64_RS08810 (ETT64_08805) recA 1707175..1708311 (-) 1137 WP_023612663.1 recombinase RecA Machinery gene
  ETT64_RS08815 (ETT64_08810) cinA 1708400..1709671 (-) 1272 WP_136021357.1 competence/damage-inducible protein A Machinery gene
  ETT64_RS08820 (ETT64_08815) - 1709740..1710300 (-) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  ETT64_RS08825 (ETT64_08820) ruvA 1710310..1710906 (-) 597 WP_136293040.1 Holliday junction branch migration protein RuvA -
  ETT64_RS08830 (ETT64_08825) - 1710908..1712128 (-) 1221 WP_002992187.1 MFS transporter -
  ETT64_RS08835 (ETT64_08830) mutL 1712139..1714121 (-) 1983 WP_002992189.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45962.68 Da        Isoelectric Point: 4.7648

>NTDB_id=341455 ETT64_RS08815 WP_136021357.1 1708400..1709671(-) (cinA) [Streptococcus pyogenes strain emm64.3]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSQKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341455 ETT64_RS08815 WP_136021357.1 1708400..1709671(-) (cinA) [Streptococcus pyogenes strain emm64.3]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCAAAAAACTCTTGAAGGTCAACCCTTAGCAGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-241)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

69.784

98.582

0.688
  cinA Streptococcus mitis NCTC 12261

69.305

98.582

0.683
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment