Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   ETT69_RS09250 Genome accession   NZ_CP035430
Coordinates   1815179..1816450 (-) Length   423 a.a.
NCBI ID   WP_030126182.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm55     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1805459..1833357 1815179..1816450 within 0


Gene organization within MGE regions


Location: 1805459..1833357
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT69_RS09200 (ETT69_09190) nrdG 1805459..1806073 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  ETT69_RS09205 (ETT69_09195) - 1806088..1806582 (-) 495 WP_014407930.1 GNAT family N-acetyltransferase -
  ETT69_RS09210 (ETT69_09200) - 1806591..1807526 (-) 936 WP_009880789.1 Gfo/Idh/MocA family protein -
  ETT69_RS09790 - 1807555..1807701 (-) 147 WP_002982210.1 hypothetical protein -
  ETT69_RS09215 (ETT69_09205) nrdD 1807883..1810081 (-) 2199 WP_002992831.1 anaerobic ribonucleoside-triphosphate reductase -
  ETT69_RS09220 (ETT69_09210) - 1810178..1811737 (-) 1560 WP_115354331.1 DUF2079 domain-containing protein -
  ETT69_RS09225 (ETT69_09215) - 1812150..1812455 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  ETT69_RS09230 (ETT69_09220) ruvX 1812467..1812886 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  ETT69_RS09235 (ETT69_09225) - 1812883..1813152 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  ETT69_RS09240 (ETT69_09230) spx 1813265..1813663 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  ETT69_RS09245 (ETT69_09235) recA 1813954..1815090 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  ETT69_RS09250 (ETT69_09240) cinA 1815179..1816450 (-) 1272 WP_030126182.1 competence/damage-inducible protein A Machinery gene
  ETT69_RS09255 (ETT69_09245) - 1816519..1817079 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  ETT69_RS09260 (ETT69_09250) ruvA 1817089..1817685 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA -
  ETT69_RS09265 (ETT69_09255) - 1817687..1818907 (-) 1221 WP_032461237.1 MFS transporter -
  ETT69_RS09270 (ETT69_09260) mutL 1818918..1820900 (-) 1983 WP_136019166.1 DNA mismatch repair endonuclease MutL -
  ETT69_RS09275 (ETT69_09265) - 1820995..1822146 (-) 1152 WP_175384546.1 site-specific integrase -
  ETT69_RS10085 (ETT69_09270) - 1822463..1822606 (+) 144 WP_011185066.1 putative holin-like toxin -
  ETT69_RS10185 - 1823743..1823976 (-) 234 Protein_1737 helix-turn-helix domain-containing protein -
  ETT69_RS09290 (ETT69_09280) - 1824128..1824355 (+) 228 WP_039994923.1 helix-turn-helix domain-containing protein -
  ETT69_RS09295 (ETT69_09285) - 1824369..1824971 (+) 603 WP_136019167.1 BRO family protein -
  ETT69_RS09300 (ETT69_09290) - 1824992..1825399 (+) 408 WP_002992501.1 hypothetical protein -
  ETT69_RS09305 (ETT69_09295) - 1825412..1826041 (+) 630 WP_022555253.1 Rha family transcriptional regulator -
  ETT69_RS09310 (ETT69_09300) - 1826286..1826618 (+) 333 WP_002992497.1 hypothetical protein -
  ETT69_RS09315 (ETT69_09305) - 1826615..1826836 (+) 222 WP_010922763.1 hypothetical protein -
  ETT69_RS09320 (ETT69_09310) - 1826839..1827030 (+) 192 WP_111681408.1 hypothetical protein -
  ETT69_RS09325 (ETT69_09315) - 1827043..1827405 (+) 363 WP_000206026.1 hypothetical protein -
  ETT69_RS09330 (ETT69_09320) - 1827402..1827731 (+) 330 WP_111704869.1 hypothetical protein -
  ETT69_RS09335 (ETT69_09325) - 1827734..1828006 (+) 273 WP_136019168.1 hypothetical protein -
  ETT69_RS09340 (ETT69_09330) - 1828007..1828864 (+) 858 WP_136019169.1 primase alpha helix C-terminal domain-containing protein -
  ETT69_RS09345 (ETT69_09335) - 1828833..1830521 (+) 1689 WP_136019170.1 phage/plasmid primase, P4 family -
  ETT69_RS09350 (ETT69_09340) - 1830808..1830981 (+) 174 WP_068791229.1 DUF2758 domain-containing protein -
  ETT69_RS09795 - 1830987..1831160 (+) 174 WP_023610070.1 hypothetical protein -
  ETT69_RS09355 (ETT69_09345) - 1831162..1831671 (+) 510 WP_136019171.1 hypothetical protein -
  ETT69_RS09360 (ETT69_09350) - 1831745..1832233 (+) 489 WP_136019172.1 hypothetical protein -
  ETT69_RS09365 (ETT69_09355) - 1832637..1832999 (+) 363 WP_002992136.1 DUF1492 domain-containing protein -
  ETT69_RS09370 (ETT69_09360) - 1832974..1833357 (+) 384 WP_136019173.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45989.79 Da        Isoelectric Point: 4.9844

>NTDB_id=341191 ETT69_RS09250 WP_030126182.1 1815179..1816450(-) (cinA) [Streptococcus pyogenes strain emm55]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDKQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=341191 ETT69_RS09250 WP_030126182.1 1815179..1816450(-) (cinA) [Streptococcus pyogenes strain emm55]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATAAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.976

100

0.7
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment