Detailed information NTG0338661

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH16_RS11010
• Genome accession: NZ_CP035264
• Coordinates: 2115617..2116369 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901921
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2110617..2121369

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH16_RS10990 (EQH16_11525)	-	2113093..2114725 (-)	1633	Protein_2156	YhgE/Pip family protein	-
EQH16_RS10995 (EQH16_11530)	-	2114832..2115374 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH16_RS11010 (EQH16_11545)	comE	2115617..2116369 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH16_RS11015 (EQH16_11550)	comD/comD1	2116366..2117691 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
EQH16_RS11020 (EQH16_11555)	comC/comC1	2117712..2117837 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH16_RS11030 (EQH16_11565)	rlmH	2118119..2118598 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH16_RS11035 (EQH16_11570)	htrA	2118781..2119962 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
EQH16_RS11040 (EQH16_11575)	spo0J	2120020..2120778 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=338661 EQH16_RS11010 WP_000866065.1 2115617..2116369(-) (comE) [Streptococcus pneumoniae strain TVO_1901921]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=338661 EQH16_RS11010 WP_000866065.1 2115617..2116369(-) (comE) [Streptococcus pneumoniae strain TVO_1901921]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408