Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   EQH26_RS09560 Genome accession   NZ_CP035254
Coordinates   1866300..1867556 (-) Length   418 a.a.
NCBI ID   WP_000642707.1    Uniprot ID   A0A0B7L5W3
Organism   Streptococcus pneumoniae strain TVO_1901932     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1859420..1881392 1866300..1867556 within 0


Gene organization within MGE regions


Location: 1859420..1881392
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH26_RS09520 (EQH26_10035) - 1859420..1860004 (-) 585 WP_001101206.1 hypothetical protein -
  EQH26_RS09525 (EQH26_10040) - 1860412..1860744 (-) 333 WP_224781448.1 hypothetical protein -
  EQH26_RS09530 (EQH26_10045) - 1860968..1861324 (-) 357 Protein_1875 ImmA/IrrE family metallo-endopeptidase -
  EQH26_RS09535 (EQH26_10050) - 1861370..1861576 (-) 207 WP_000366086.1 hypothetical protein -
  EQH26_RS09540 (EQH26_10055) - 1861563..1861724 (-) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  EQH26_RS09545 (EQH26_10060) lytA 1862070..1863026 (-) 957 WP_000405240.1 N-acetylmuramoyl-L-alanine amidase LytA -
  EQH26_RS09550 (EQH26_10065) - 1863402..1864772 (-) 1371 WP_001036286.1 MATE family efflux transporter -
  EQH26_RS09555 (EQH26_10070) recA 1865079..1866245 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  EQH26_RS09560 (EQH26_10075) cinA 1866300..1867556 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  EQH26_RS09565 (EQH26_10080) brpA 1867641..1868657 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  EQH26_RS09570 (EQH26_10085) - 1868665..1869183 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  EQH26_RS09575 (EQH26_10090) tsaE 1869173..1869616 (-) 444 WP_000275589.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  EQH26_RS09580 (EQH26_10095) comM 1869702..1870322 (-) 621 WP_000839908.1 hypothetical protein Regulator
  EQH26_RS09585 (EQH26_10105) - 1870705..1871568 (-) 864 WP_001093620.1 helix-turn-helix domain-containing protein -
  EQH26_RS10880 (EQH26_10110) - 1871760..1871930 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  EQH26_RS09590 (EQH26_10115) pneA1 1872033..1872257 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  EQH26_RS09595 (EQH26_10120) pneA2 1872264..1872452 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  EQH26_RS09600 (EQH26_10125) - 1872570..1875560 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  EQH26_RS09605 (EQH26_10130) - 1875910..1876614 (+) 705 WP_001033170.1 flavodoxin family protein -
  EQH26_RS09610 (EQH26_10135) - 1876595..1877524 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  EQH26_RS09615 (EQH26_10140) - 1877521..1879629 (+) 2109 WP_000701299.1 peptidase domain-containing ABC transporter -
  EQH26_RS09620 (EQH26_10145) - 1879653..1881392 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45061.46 Da        Isoelectric Point: 4.6027

>NTDB_id=337943 EQH26_RS09560 WP_000642707.1 1866300..1867556(-) (cinA) [Streptococcus pneumoniae strain TVO_1901932]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=337943 EQH26_RS09560 WP_000642707.1 1866300..1867556(-) (cinA) [Streptococcus pneumoniae strain TVO_1901932]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGTTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGATCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7L5W3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.761

100

0.998
  cinA Streptococcus pneumoniae Rx1

99.522

100

0.995
  cinA Streptococcus pneumoniae R6

99.522

100

0.995
  cinA Streptococcus pneumoniae D39

99.282

100

0.993
  cinA Streptococcus mitis SK321

93.78

100

0.938
  cinA Streptococcus mitis NCTC 12261

93.541

100

0.935
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment