Detailed information NTG0337717

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH31_RS10975
• Genome accession: NZ_CP035249
• Coordinates: 2136157..2136909 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901938
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2131157..2141909

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH31_RS10945 (EQH31_11630)	-	2132170..2133517 (-)	1348	Protein_2143	IS3 family transposase	-
EQH31_RS11255	-	2133590..2135193 (-)	1604	Protein_2144	YhgE/Pip family protein	-
EQH31_RS10960 (EQH31_11645)	-	2135372..2135914 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH31_RS10975 (EQH31_11660)	comE	2136157..2136909 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH31_RS10980 (EQH31_11665)	comD/comD1	2136906..2138231 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
EQH31_RS10985 (EQH31_11670)	comC/comC1	2138252..2138377 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH31_RS10995 (EQH31_11680)	rlmH	2138659..2139138 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH31_RS11000 (EQH31_11685)	htrA	2139321..2140502 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
EQH31_RS11005 (EQH31_11690)	spo0J	2140560..2141318 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337717 EQH31_RS10975 WP_000866065.1 2136157..2136909(-) (comE) [Streptococcus pneumoniae strain TVO_1901938]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337717 EQH31_RS10975 WP_000866065.1 2136157..2136909(-) (comE) [Streptococcus pneumoniae strain TVO_1901938]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408