Detailed information NTG0033201

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SPJ_RS11235
• Genome accession: NC_012466
• Coordinates: 2118221..2119402 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681598.1
• Uniprot ID: A0A0B7M448
• Organism: Streptococcus pneumoniae JJA
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2113221..2124402

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPJ_RS11195 (SPJ_2261)	-	2114272..2114814 (+)	543	WP_001158269.1	TetR/AcrR family transcriptional regulator	-
SPJ_RS11210 (SPJ_2264)	comE	2115057..2115809 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPJ_RS11215 (SPJ_2265)	comD/comD2	2115806..2117131 (-)	1326	WP_000364843.1	competence system sensor histidine kinase ComD	Regulator
SPJ_RS11220 (SPJ_2266)	comC/comC2	2117152..2117277 (-)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
SPJ_RS11230 (SPJ_2268)	rlmH	2117559..2118038 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPJ_RS11235 (SPJ_2269)	htrA	2118221..2119402 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
SPJ_RS11240 (SPJ_2270)	spo0J	2119460..2120218 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41827.69 Da
• Isoelectric Point: 6.8902

>NTDB_id=33201 SPJ_RS11235 WP_000681598.1 2118221..2119402(+) (htrA) [Streptococcus pneumoniae JJA]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=33201 SPJ_RS11235 WP_000681598.1 2118221..2119402(+) (htrA) [Streptococcus pneumoniae JJA]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAATAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7M448

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.746	100	0.997
htrA	Streptococcus pneumoniae D39	99.746	100	0.997
htrA	Streptococcus pneumoniae R6	99.746	100	0.997
htrA	Streptococcus pneumoniae TIGR4	99.746	100	0.997
htrA	Streptococcus mitis NCTC 12261	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.822	100	0.55