Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   SPJ_RS11210 Genome accession   NC_012466
Coordinates   2115057..2115809 (-) Length   250 a.a.
NCBI ID   WP_000866065.1    Uniprot ID   -
Organism   Streptococcus pneumoniae JJA     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2110057..2120809
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPJ_RS13620 - 2112490..2114093 (-) 1604 Protein_2106 YhgE/Pip domain-containing protein -
  SPJ_RS11195 (SPJ_2261) - 2114272..2114814 (+) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  SPJ_RS11210 (SPJ_2264) comE 2115057..2115809 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  SPJ_RS11215 (SPJ_2265) comD/comD2 2115806..2117131 (-) 1326 WP_000364843.1 competence system sensor histidine kinase ComD Regulator
  SPJ_RS11220 (SPJ_2266) comC/comC2 2117152..2117277 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  SPJ_RS11230 (SPJ_2268) rlmH 2117559..2118038 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SPJ_RS11235 (SPJ_2269) htrA 2118221..2119402 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  SPJ_RS11240 (SPJ_2270) spo0J 2119460..2120218 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29958.31 Da        Isoelectric Point: 6.5073

>NTDB_id=33198 SPJ_RS11210 WP_000866065.1 2115057..2115809(-) (comE) [Streptococcus pneumoniae JJA]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=33198 SPJ_RS11210 WP_000866065.1 2115057..2115809(-) (comE) [Streptococcus pneumoniae JJA]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATTGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

100

100

1
  comE Streptococcus pneumoniae D39

100

100

1
  comE Streptococcus pneumoniae R6

100

100

1
  comE Streptococcus pneumoniae TIGR4

100

100

1
  comE Streptococcus mitis SK321

99.2

100

0.992
  comE Streptococcus mitis NCTC 12261

98.4

100

0.984
  comE Streptococcus infantis strain Atu-4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.8

100

0.628
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.8

100

0.628
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment