Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   EGC57_RS09135 Genome accession   NZ_CP033621
Coordinates   1782729..1784000 (-) Length   423 a.a.
NCBI ID   WP_076639529.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain M75     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1777729..1789000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EGC57_RS09110 (EGC57_09125) - 1779696..1780001 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  EGC57_RS09115 (EGC57_09130) ruvX 1780013..1780432 (-) 420 WP_063632439.1 Holliday junction resolvase RuvX -
  EGC57_RS09120 (EGC57_09135) - 1780429..1780698 (-) 270 WP_063632440.1 IreB family regulatory phosphoprotein -
  EGC57_RS09125 (EGC57_09140) spx 1780812..1781210 (-) 399 WP_076639527.1 transcriptional regulator Spx -
  EGC57_RS09130 (EGC57_09145) recA 1781504..1782640 (-) 1137 WP_076639528.1 recombinase RecA Machinery gene
  EGC57_RS09135 (EGC57_09150) cinA 1782729..1784000 (-) 1272 WP_076639529.1 competence/damage-inducible protein A Machinery gene
  EGC57_RS09140 (EGC57_09155) - 1784069..1784629 (-) 561 WP_002992183.1 DNA-3-methyladenine glycosylase I -
  EGC57_RS09145 (EGC57_09160) ruvA 1784639..1785235 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA -
  EGC57_RS09150 (EGC57_09165) - 1785237..1786457 (-) 1221 WP_076639530.1 MFS transporter -
  EGC57_RS09155 (EGC57_09170) mutL 1786468..1788450 (-) 1983 WP_002992189.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45917.64 Da        Isoelectric Point: 4.7648

>NTDB_id=324504 EGC57_RS09135 WP_076639529.1 1782729..1784000(-) (cinA) [Streptococcus pyogenes strain M75]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRRDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPI
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVAYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
CYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=324504 EGC57_RS09135 WP_076639529.1 1782729..1784000(-) (cinA) [Streptococcus pyogenes strain M75]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGGAGTGATTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAGAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGATCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATTACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATA
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGGCTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
TGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.065

98.582

0.681
  cinA Streptococcus mitis NCTC 12261

68.585

98.582

0.676
  cinA Streptococcus pneumoniae TIGR4

67.626

98.582

0.667
  cinA Streptococcus pneumoniae Rx1

67.626

98.582

0.667
  cinA Streptococcus pneumoniae R6

67.626

98.582

0.667
  cinA Streptococcus pneumoniae D39

67.386

98.582

0.664
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment