Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   D8S77_RS08860 Genome accession   NZ_CP032700
Coordinates   1754433..1755704 (-) Length   423 a.a.
NCBI ID   WP_129322339.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY556     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1749433..1760704
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D8S77_RS08830 (D8S77_08845) - 1749433..1750992 (-) 1560 WP_030126183.1 membrane protein -
  D8S77_RS08835 (D8S77_08850) - 1751404..1751709 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  D8S77_RS08840 (D8S77_08855) ruvX 1751721..1752140 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  D8S77_RS08845 (D8S77_08860) - 1752137..1752406 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  D8S77_RS08850 (D8S77_08865) spx 1752519..1752917 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  D8S77_RS08855 (D8S77_08870) recA 1753208..1754344 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  D8S77_RS08860 (D8S77_08875) cinA 1754433..1755704 (-) 1272 WP_129322339.1 competence/damage-inducible protein A Machinery gene
  D8S77_RS08865 (D8S77_08880) - 1755773..1756333 (-) 561 WP_129322341.1 DNA-3-methyladenine glycosylase I -
  D8S77_RS08870 (D8S77_08885) ruvA 1756343..1756939 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA -
  D8S77_RS08875 (D8S77_08890) - 1756941..1758161 (-) 1221 WP_002991361.1 MDR family MFS transporter -
  D8S77_RS08880 (D8S77_08895) mutL 1758172..1760154 (-) 1983 WP_129322343.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45973.71 Da        Isoelectric Point: 4.9060

>NTDB_id=318343 D8S77_RS08860 WP_129322339.1 1754433..1755704(-) (cinA) [Streptococcus pyogenes strain TSPY556]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASHRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSISLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLAGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKIESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=318343 D8S77_RS08860 WP_129322339.1 1754433..1755704(-) (cinA) [Streptococcus pyogenes strain TSPY556]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCATCGTAGTGACTTGGTGATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCTCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GCTATTGGCTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGATAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.267

100

0.693
  cinA Streptococcus mitis SK321

69.305

98.582

0.683
  cinA Streptococcus mitis NCTC 12261

68.825

98.582

0.678
  cinA Streptococcus pneumoniae TIGR4

67.866

98.582

0.669
  cinA Streptococcus pneumoniae Rx1

67.866

98.582

0.669
  cinA Streptococcus pneumoniae R6

67.866

98.582

0.669
  cinA Streptococcus pneumoniae D39

67.626

98.582

0.667
  cinA Streptococcus suis isolate S10

53.365

98.345

0.525
  cinA Bacillus subtilis subsp. subtilis str. 168

46.411

98.818

0.459

Multiple sequence alignment