Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MGAS27961_RS08795 Genome accession   NZ_CP032665
Coordinates   1756181..1757452 (-) Length   423 a.a.
NCBI ID   WP_011285266.1    Uniprot ID   Q48QW6
Organism   Streptococcus pyogenes strain MGAS27961     
Function   require for competence (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1746459..1776869 1756181..1757452 within 0


Gene organization within MGE regions


Location: 1746459..1776869
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS27961_RS08745 (MGAS27961_08745) nrdG 1746459..1747073 (-) 615 WP_002982219.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  MGAS27961_RS08750 (MGAS27961_08750) - 1747073..1747582 (-) 510 WP_011285262.1 GNAT family N-acetyltransferase -
  MGAS27961_RS08755 (MGAS27961_08755) - 1747591..1748526 (-) 936 WP_002992828.1 Gfo/Idh/MocA family protein -
  MGAS27961_RS09510 - 1748555..1748701 (-) 147 WP_002982210.1 hypothetical protein -
  MGAS27961_RS08760 (MGAS27961_08760) nrdD 1748883..1751081 (-) 2199 WP_011285263.1 anaerobic ribonucleoside-triphosphate reductase -
  MGAS27961_RS08765 (MGAS27961_08765) - 1751178..1752737 (-) 1560 WP_011285264.1 membrane protein -
  MGAS27961_RS08770 (MGAS27961_08770) - 1753151..1753456 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  MGAS27961_RS08775 (MGAS27961_08775) ruvX 1753468..1753887 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  MGAS27961_RS08780 (MGAS27961_08780) - 1753884..1754153 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  MGAS27961_RS08785 (MGAS27961_08785) spx 1754267..1754665 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  MGAS27961_RS08790 (MGAS27961_08790) recA 1754956..1756092 (-) 1137 WP_011285265.1 recombinase RecA Machinery gene
  MGAS27961_RS08795 (MGAS27961_08795) cinA 1756181..1757452 (-) 1272 WP_011285266.1 competence/damage-inducible protein A Machinery gene
  MGAS27961_RS08800 (MGAS27961_08800) - 1757521..1758081 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  MGAS27961_RS08805 (MGAS27961_08805) ruvA 1758091..1758687 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA -
  MGAS27961_RS08810 (MGAS27961_08810) - 1758689..1759909 (-) 1221 WP_011285269.1 MFS transporter -
  MGAS27961_RS08815 (MGAS27961_08815) mutL 1759920..1761902 (-) 1983 WP_021340699.1 DNA mismatch repair endonuclease MutL -
  MGAS27961_RS08820 (MGAS27961_08820) - 1761997..1763148 (-) 1152 WP_003058754.1 site-specific integrase -
  MGAS27961_RS08825 (MGAS27961_08825) - 1763397..1763540 (+) 144 WP_011185066.1 putative holin-like toxin -
  MGAS27961_RS08830 (MGAS27961_08830) - 1764402..1765169 (-) 768 WP_003058809.1 helix-turn-helix transcriptional regulator -
  MGAS27961_RS08835 (MGAS27961_08835) - 1765323..1765529 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  MGAS27961_RS08840 (MGAS27961_08840) - 1765563..1765763 (+) 201 WP_002992502.1 helix-turn-helix domain-containing protein -
  MGAS27961_RS08845 (MGAS27961_08845) - 1765784..1766191 (+) 408 WP_002992501.1 hypothetical protein -
  MGAS27961_RS09660 - 1766204..1766326 (+) 123 WP_011285272.1 hypothetical protein -
  MGAS27961_RS08850 (MGAS27961_08850) - 1766609..1767130 (+) 522 WP_002992498.1 Rha family transcriptional regulator -
  MGAS27961_RS08855 (MGAS27961_08855) - 1767378..1767551 (+) 174 WP_000132665.1 hypothetical protein -
  MGAS27961_RS08860 (MGAS27961_08860) - 1767769..1767942 (+) 174 WP_000074663.1 plasmid mobilization protein -
  MGAS27961_RS08865 (MGAS27961_08865) - 1768104..1768535 (+) 432 WP_136302445.1 hypothetical protein -
  MGAS27961_RS08870 (MGAS27961_08870) - 1768623..1768805 (+) 183 WP_011285318.1 hypothetical protein -
  MGAS27961_RS08875 (MGAS27961_08875) - 1768817..1769149 (+) 333 WP_127821322.1 hypothetical protein -
  MGAS27961_RS08880 (MGAS27961_08880) - 1769149..1769340 (+) 192 WP_021340709.1 hypothetical protein -
  MGAS27961_RS08885 (MGAS27961_08885) - 1769352..1769681 (+) 330 WP_003058810.1 hypothetical protein -
  MGAS27961_RS08890 (MGAS27961_08890) - 1769684..1769956 (+) 273 WP_010922766.1 hypothetical protein -
  MGAS27961_RS08895 (MGAS27961_08895) - 1769957..1770823 (+) 867 WP_011285278.1 primase alpha helix C-terminal domain-containing protein -
  MGAS27961_RS08900 (MGAS27961_08900) - 1770835..1772229 (+) 1395 WP_011285279.1 VapE domain-containing protein -
  MGAS27961_RS08905 (MGAS27961_08905) - 1772523..1772777 (+) 255 WP_011285280.1 hypothetical protein -
  MGAS27961_RS08910 (MGAS27961_08910) - 1772774..1772947 (+) 174 WP_068791229.1 DUF2758 domain-containing protein -
  MGAS27961_RS09515 - 1772953..1773126 (+) 174 WP_011285282.1 hypothetical protein -
  MGAS27961_RS08915 (MGAS27961_08915) - 1773128..1773463 (+) 336 Protein_1667 hypothetical protein -
  MGAS27961_RS08920 (MGAS27961_08920) - 1773462..1773695 (+) 234 WP_014407966.1 hypothetical protein -
  MGAS27961_RS09520 - 1773709..1773867 (+) 159 WP_011285309.1 hypothetical protein -
  MGAS27961_RS08925 (MGAS27961_08925) - 1773958..1774746 (+) 789 WP_011285308.1 hypothetical protein -
  MGAS27961_RS08930 (MGAS27961_08930) - 1774743..1775009 (+) 267 WP_011285307.1 hypothetical protein -
  MGAS27961_RS08935 (MGAS27961_08935) - 1775006..1775389 (+) 384 WP_011285306.1 hypothetical protein -
  MGAS27961_RS08940 (MGAS27961_08940) - 1775379..1775654 (+) 276 WP_014407964.1 hypothetical protein -
  MGAS27961_RS08945 (MGAS27961_08945) - 1775629..1775874 (+) 246 WP_011285304.1 hypothetical protein -
  MGAS27961_RS08950 (MGAS27961_08950) - 1776155..1776517 (+) 363 WP_127821323.1 DUF1492 domain-containing protein -
  MGAS27961_RS08955 (MGAS27961_08955) - 1776492..1776869 (+) 378 WP_020905579.1 ArpU family phage packaging/lysis transcriptional regulator -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45990.74 Da        Isoelectric Point: 4.8322

>NTDB_id=317776 MGAS27961_RS08795 WP_011285266.1 1756181..1757452(-) (cinA) [Streptococcus pyogenes strain MGAS27961]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=317776 MGAS27961_RS08795 WP_011285266.1 1756181..1757452(-) (cinA) [Streptococcus pyogenes strain MGAS27961]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGCCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q48QW6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461

Multiple sequence alignment