Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   D7D53_RS09085 Genome accession   NZ_CP032621
Coordinates   1796642..1797823 (-) Length   393 a.a.
NCBI ID   WP_120770758.1    Uniprot ID   A0A387BD98
Organism   Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1791642..1802823
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D7D53_RS09065 (D7D53_09065) - 1792698..1792892 (-) 195 WP_000285186.1 DUF951 domain-containing protein -
  D7D53_RS09070 (D7D53_09070) dnaN 1792957..1794093 (-) 1137 WP_042751910.1 DNA polymerase III subunit beta -
  D7D53_RS09075 (D7D53_09075) dnaA 1794252..1795613 (-) 1362 WP_120770756.1 chromosomal replication initiator protein DnaA -
  D7D53_RS09080 (D7D53_09080) spo0J 1795826..1796584 (-) 759 WP_120770757.1 ParB/RepB/Spo0J family partition protein Regulator
  D7D53_RS09085 (D7D53_09085) htrA 1796642..1797823 (-) 1182 WP_120770758.1 S1C family serine protease Regulator
  D7D53_RS09090 (D7D53_09090) rlmH 1798007..1798486 (+) 480 WP_120770759.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  D7D53_RS09100 (D7D53_09100) comC/comC2 1798770..1798892 (+) 123 WP_120770760.1 competence-stimulating peptide ComC Regulator
  D7D53_RS09105 (D7D53_09105) comD/comD2 1798909..1800258 (+) 1350 WP_120770761.1 competence system sensor histidine kinase ComD Regulator
  D7D53_RS09110 (D7D53_09110) comE 1800255..1801007 (+) 753 WP_033682534.1 competence system response regulator transcription factor ComE Regulator
  D7D53_RS09125 (D7D53_09125) - 1801250..1801792 (-) 543 WP_049552685.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41794.65 Da        Isoelectric Point: 6.1475

>NTDB_id=317227 D7D53_RS09085 WP_120770758.1 1796642..1797823(-) (htrA) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
MKHLKTFYKKWFQLLVVIVISFISGALGSFSINQLTQKSTISTSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=317227 D7D53_RS09085 WP_120770758.1 1796642..1797823(-) (htrA) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTATTAGTGGAGCCTT
GGGTAGCTTTTCAATAAACCAACTAACTCAAAAAAGTACTATAAGTACCTCTAACAACAATAGTACTATTACACAGACTG
CCTATAAGAATGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCCGTTGTATCTGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACTGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGATAAAGAAGCTTATATTGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCTGGAGAAATTGTCGGAGCGGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTTACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATTGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCAATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAAGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATACCTGCAAATGATGCTATCAATATTATTGAACAGTTGGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGCATCC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATATTAGAAGACTGAATATTCCAAGCAATGTAACATCTGGTGTAGTT
GTTCGTTCTGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATTGCTTCATCAACAGATTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(289-384)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A387BD98

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

98.982

100

0.99
  htrA Streptococcus pneumoniae Rx1

96.947

100

0.969
  htrA Streptococcus pneumoniae D39

96.947

100

0.969
  htrA Streptococcus pneumoniae R6

96.947

100

0.969
  htrA Streptococcus pneumoniae TIGR4

96.947

100

0.969
  htrA Streptococcus gordonii str. Challis substr. CH1

66.499

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment