Detailed information NTG0315813

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLW34_RS04430
• Genome accession: NZ_CP032430
• Coordinates: 863275..863967 (+)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain W34
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 858275..868967

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLW34_RS04400 (LLW34_0855)	arsC	858932..859336 (+)	405	WP_021165525.1	arsenate reductase (thioredoxin)	-
LLW34_RS04405 (LLW34_0856)	-	859448..860284 (+)	837	WP_031288631.1	metallophosphoesterase	-
LLW34_RS04410 (LLW34_02870)	-	860377..861288 (+)	912	Protein_851	CHAP domain-containing protein	-
LLW34_RS04415 (LLW34_02875)	-	861525..861887 (+)	363	Protein_852	TIGR02328 family protein	-
LLW34_RS04420 (LLW34_0859)	-	862211..862456 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLW34_RS04425 (LLW34_0860)	-	862589..863119 (+)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLW34_RS04430 (LLW34_0861)	covR	863275..863967 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLW34_RS04435 (LLW34_0862)	covS	863980..865452 (+)	1473	WP_205288384.1	HAMP domain-containing histidine kinase	Regulator
LLW34_RS04440 (LLW34_0863)	-	865638..866879 (+)	1242	WP_205288385.1	ammonium transporter	-
LLW34_RS04445 (LLW34_0864)	-	866964..867305 (+)	342	WP_205288386.1	P-II family nitrogen regulator	-
LLW34_RS04450 (LLW34_0865)	murD	867474..868823 (+)	1350	WP_021211936.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=315813 LLW34_RS04430 WP_011676631.1 863275..863967(+) (covR) [Lactococcus cremoris strain W34]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=315813 LLW34_RS04430 WP_011676631.1 863275..863967(+) (covR) [Lactococcus cremoris strain W34]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361