Detailed information NTG0313527

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: D2E16_RS04920
• Genome accession: NZ_CP032064
• Coordinates: 1033322..1033993 (+)
• Length: 223 a.a.
• NCBI ID: WP_002940863.1
• Uniprot ID: A0A2I5N3I8
• Organism: Streptococcus suis strain YSJ17
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1028322..1038993

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
D2E16_RS04890 (D2E16_05010)	pstA	1028484..1029371 (+)	888	WP_029177889.1	phosphate ABC transporter permease PstA	-
D2E16_RS04895 (D2E16_05015)	pstB	1029396..1030199 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
D2E16_RS04900 (D2E16_05020)	pstB	1030211..1030969 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
D2E16_RS04905 (D2E16_05025)	phoU	1030998..1031654 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
D2E16_RS04910 (D2E16_05030)	tnpA	1031834..1032366 (+)	533	Protein_925	IS200/IS605 family transposase	-
D2E16_RS12525	-	1032629..1033177 (+)	549	WP_225620836.1	hypothetical protein	-
D2E16_RS04920 (D2E16_05045)	ciaR	1033322..1033993 (+)	672	WP_002940863.1	response regulator transcription factor	Regulator
D2E16_RS04925 (D2E16_05050)	ciaH	1033986..1035365 (+)	1380	WP_192370208.1	sensor histidine kinase	Regulator
D2E16_RS04930 (D2E16_05055)	-	1035466..1036716 (+)	1251	WP_192370206.1	transglutaminase domain-containing protein	-
D2E16_RS04935 (D2E16_05060)	-	1036861..1038349 (-)	1489	Protein_930	IS1182 family transposase	-
D2E16_RS04940 (D2E16_05065)	rpsT	1038475..1038723 (-)	249	WP_012027069.1	30S ribosomal protein S20	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25261.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=313527 D2E16_RS04920 WP_002940863.1 1033322..1033993(+) (ciaR) [Streptococcus suis strain YSJ17]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=313527 D2E16_RS04920 WP_002940863.1 1033322..1033993(+) (ciaR) [Streptococcus suis strain YSJ17]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGTCTTTCGAATTCTGTTTTTGATTTTCTAGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGCCTTGAAGATAAAGGTCACGGATTTGAATTAGGTGCAGATGATTATTTGACCAAGCCATTTTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCCTTATTAAAGAGATCGGGCAAGTTTAATGAAAACACACTGACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACGACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A2I5N3I8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.583	100	0.906
ciaR	Streptococcus pneumoniae Rx1	89.238	100	0.892
ciaR	Streptococcus pneumoniae D39	89.238	100	0.892
ciaR	Streptococcus pneumoniae R6	89.238	100	0.892
ciaR	Streptococcus pneumoniae TIGR4	89.238	100	0.892
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.611	100	0.381
vicR	Streptococcus mutans UA159	35.897	100	0.377
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.363