Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   EB814_RS12405 Genome accession   NZ_CP035545
Coordinates   2479306..2479962 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain FSIS11705876     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2474306..2484962
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB814_RS28205 (EB814_12770) - 2475275..2475442 (-) 168 Protein_2455 hypothetical protein -
  EB814_RS12370 (EB814_12775) - 2475384..2475578 (-) 195 WP_115801851.1 hypothetical protein -
  EB814_RS12375 (EB814_12780) - 2475599..2475880 (-) 282 WP_001303543.1 hypothetical protein -
  EB814_RS12395 (EB814_12800) pgsA 2476872..2477420 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  EB814_RS12400 (EB814_12805) uvrC 2477477..2479309 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  EB814_RS12405 (EB814_12810) letA 2479306..2479962 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  EB814_RS28570 (EB814_12815) - 2480104..2480220 (+) 117 WP_001302039.1 hypothetical protein -
  EB814_RS12410 (EB814_12820) yecU 2480258..2480434 (+) 177 WP_001302050.1 protein YecU -
  EB814_RS12415 (EB814_12825) yecF 2480421..2480645 (+) 225 WP_000106478.1 DUF2594 family protein YecF -
  EB814_RS12420 (EB814_12830) sdiA 2480713..2481435 (-) 723 WP_001154288.1 transcriptional regulator SdiA -
  EB814_RS12425 (EB814_12835) tcyN 2481665..2482417 (-) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  EB814_RS12430 (EB814_12840) tcyL 2482414..2483082 (-) 669 WP_001158226.1 cystine ABC transporter permease -
  EB814_RS12435 (EB814_12845) dcyD 2483097..2484083 (-) 987 WP_001128225.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=304063 EB814_RS12405 WP_000611328.1 2479306..2479962(-) (letA) [Escherichia coli strain FSIS11705876]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=304063 EB814_RS12405 WP_000611328.1 2479306..2479962(-) (letA) [Escherichia coli strain FSIS11705876]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482

Multiple sequence alignment