Detailed information NTG0302344

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: DR994_RS02125
• Genome accession: NZ_CP030927
• Coordinates: 394419..395126 (-)
• Length: 235 a.a.
• NCBI ID: WP_173940375.1
• Uniprot ID: A0A2H4K9R7
• Organism: Streptococcus thermophilus strain CS9
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 389419..400126

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DR994_RS02100 (DR994_02155)	yidA	389728..390537 (+)	810	WP_011226081.1	sugar-phosphatase	-
DR994_RS02105 (DR994_02160)	-	390539..391753 (+)	1215	WP_173940373.1	aminoacyltransferase	-
DR994_RS02110 (DR994_02165)	-	391805..392166 (-)	362	Protein_372	YbaN family protein	-
DR994_RS02115 (DR994_02170)	vicX	392226..393038 (-)	813	WP_011681204.1	MBL fold metallo-hydrolase	Regulator
DR994_RS02120 (DR994_02175)	vicK	393044..394426 (-)	1383	WP_173940374.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DR994_RS02125 (DR994_02180)	vicR	394419..395126 (-)	708	WP_173940375.1	response regulator YycF	Regulator
DR994_RS02130 (DR994_02185)	-	395653..396420 (+)	768	WP_173940376.1	amino acid ABC transporter ATP-binding protein	-
DR994_RS02135 (DR994_02190)	-	396432..397265 (+)	834	WP_022096756.1	transporter substrate-binding domain-containing protein	-
DR994_RS02140 (DR994_02195)	-	397283..397981 (+)	699	WP_022096755.1	amino acid ABC transporter permease	-
DR994_RS02145 (DR994_02200)	-	397993..398643 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
DR994_RS02150 (DR994_02205)	endA	398715..399596 (-)	882	WP_022096754.1	DNA/RNA non-specific endonuclease	Machinery gene
DR994_RS02155 (DR994_02210)	-	399658..399846 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27087.04 Da
• Isoelectric Point: 5.0130

>NTDB_id=302344 DR994_RS02125 WP_173940375.1 394419..395126(-) (vicR) [Streptococcus thermophilus strain CS9]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEIAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=302344 DR994_RS02125 WP_173940375.1 394419..395126(-) (vicR) [Streptococcus thermophilus strain CS9]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCTGAACTGGATGGTTTGGAAATTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACTGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTCCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: A0A2H4K9R7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.106	100	0.851
micA	Streptococcus pneumoniae Cp1015	79.828	99.149	0.791
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.455	98.298	0.447
covR	Streptococcus salivarius strain HSISS4	44.872	99.574	0.447
scnR	Streptococcus mutans UA159	38.136	100	0.383