Detailed information NTG0297623

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH19_RS10665
• Genome accession: NZ_CP035261
• Coordinates: 2079586..2080338 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: Q79CK7
• Organism: Streptococcus pneumoniae strain TVO_1901924
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2074586..2085338

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH19_RS10920 (EQH19_11235)	-	2077020..2078673 (-)	1654	Protein_2077	YhgE/Pip family protein	-
EQH19_RS10650 (EQH19_11240)	-	2078801..2079343 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH19_RS10665 (EQH19_11255)	comE	2079586..2080338 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH19_RS10670 (EQH19_11260)	comD	2080335..2080976 (-)	642	Protein_2080	competence system sensor histidine kinase ComD	-
EQH19_RS10675 (EQH19_11265)	-	2081143..2082489 (+)	1347	WP_001808790.1	IS1380-like element ISSpn5 family transposase	-
EQH19_RS10680 (EQH19_11270)	comD	2082682..2083368 (-)	687	Protein_2082	competence system sensor histidine kinase ComD	-
EQH19_RS10685 (EQH19_11275)	comC/comC1	2083389..2083514 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH19_RS10695 (EQH19_11285)	rlmH	2083796..2084275 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=297623 EQH19_RS10665 WP_000866065.1 2079586..2080338(-) (comE) [Streptococcus pneumoniae strain TVO_1901924]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=297623 EQH19_RS10665 WP_000866065.1 2079586..2080338(-) (comE) [Streptococcus pneumoniae strain TVO_1901924]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
TAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• PDB: 4CBV

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408