Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   EQH24_RS10525 Genome accession   NZ_CP035256
Coordinates   2012362..2013303 (-) Length   313 a.a.
NCBI ID   WP_000249559.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901930     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2007362..2018303
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH24_RS10490 (EQH24_11000) - 2007420..2008109 (+) 690 WP_000577515.1 DUF4145 domain-containing protein -
  EQH24_RS10495 (EQH24_11005) - 2008269..2008544 (-) 276 WP_001094375.1 hypothetical protein -
  EQH24_RS10500 (EQH24_11010) - 2008699..2009487 (+) 789 WP_050116194.1 S24 family peptidase -
  EQH24_RS10505 (EQH24_11015) - 2009489..2009689 (+) 201 WP_000064302.1 hypothetical protein -
  EQH24_RS10510 (EQH24_11020) - 2009871..2011316 (+) 1446 WP_061385035.1 recombinase family protein -
  EQH24_RS10520 (EQH24_11030) comGB/cglB 2011398..2012414 (-) 1017 WP_073177425.1 competence type IV pilus assembly protein ComGB Machinery gene
  EQH24_RS10525 (EQH24_11035) comGA/cglA/cilD 2012362..2013303 (-) 942 WP_000249559.1 competence type IV pilus ATPase ComGA Machinery gene
  EQH24_RS10530 (EQH24_11040) - 2013379..2013744 (-) 366 WP_000286415.1 DUF1033 family protein -
  EQH24_RS10535 (EQH24_11045) - 2014012..2015267 (+) 1256 WP_408604980.1 ISL3 family transposase -
  EQH24_RS10540 (EQH24_11050) - 2015316..2016374 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  EQH24_RS10545 (EQH24_11055) nagA 2016537..2017688 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35489.42 Da        Isoelectric Point: 6.1829

>NTDB_id=297014 EQH24_RS10525 WP_000249559.1 2012362..2013303(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901930]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHGLSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=297014 EQH24_RS10525 WP_000249559.1 2012362..2013303(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901930]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGCTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCCAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGAAGTGGTAAGACGACCTTGATGCATGGATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGATATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterProScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

98.403

100

0.984
  comGA/cglA/cilD Streptococcus pneumoniae D39

98.403

100

0.984
  comGA/cglA/cilD Streptococcus pneumoniae R6

98.403

100

0.984
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

98.403

100

0.984
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.805

100

0.968
  comGA Streptococcus gordonii str. Challis substr. CH1

78.065

99.042

0.773
  comGA Streptococcus mutans UA159

66.238

99.361

0.658
  comGA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364