Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SGO_RS05265 Genome accession   NC_009785
Coordinates   1116052..1116726 (+) Length   224 a.a.
NCBI ID   WP_012000484.1    Uniprot ID   A8AX51
Organism   Streptococcus gordonii str. Challis substr. CH1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1111052..1121726
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGO_RS05240 (SGO_1067) - 1111350..1111646 (+) 297 WP_012000479.1 hypothetical protein -
  SGO_RS05245 (SGO_1068) - 1111655..1111981 (+) 327 WP_012000480.1 hypothetical protein -
  SGO_RS05250 (SGO_1069) - 1112112..1114655 (+) 2544 WP_012000481.1 M1 family metallopeptidase -
  SGO_RS05255 (SGO_1070) - 1114712..1115254 (-) 543 WP_012000482.1 biotin transporter BioY -
  SGO_RS05260 (SGO_1071) - 1115466..1115921 (+) 456 WP_012000483.1 hypothetical protein -
  SGO_RS05265 (SGO_1072) ciaR 1116052..1116726 (+) 675 WP_012000484.1 response regulator transcription factor Regulator
  SGO_RS05270 (SGO_1073) ciaH 1116716..1118116 (+) 1401 WP_012000485.1 sensor histidine kinase Regulator
  SGO_RS05275 (SGO_1074) - 1118118..1119044 (+) 927 WP_012000486.1 ketopantoate reductase family protein -
  SGO_RS05280 (SGO_1075) - 1119068..1120519 (-) 1452 WP_012000487.1 alpha-amylase -
  SGO_RS05285 (SGO_1076) rpsT 1120746..1120994 (-) 249 WP_008808726.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25374.09 Da        Isoelectric Point: 4.3634

>NTDB_id=29073 SGO_RS05265 WP_012000484.1 1116052..1116726(+) (ciaR) [Streptococcus gordonii str. Challis substr. CH1]
MIKILLVEDNLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENNLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=29073 SGO_RS05265 WP_012000484.1 1116052..1116726(+) (ciaR) [Streptococcus gordonii str. Challis substr. CH1]
ATGATTAAGATTTTACTAGTAGAAGACAACTTAGGGTTGTCAAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATCTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGATGGCTTTCAAGTTTTGAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGAGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATAATTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAATAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AX51

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

89.732

100

0.897
  ciaR Streptococcus pneumoniae Rx1

89.732

100

0.897
  ciaR Streptococcus pneumoniae D39

89.732

100

0.897
  ciaR Streptococcus pneumoniae R6

89.732

100

0.897
  ciaR Streptococcus mutans UA159

89.686

99.554

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.556

100

0.397
  vicR Streptococcus mutans UA159

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366
  micA Streptococcus pneumoniae Cp1015

34.764

100

0.362

Multiple sequence alignment