Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SM12261_RS01770 Genome accession   NZ_CP028414
Coordinates   333939..334685 (+) Length   248 a.a.
NCBI ID   WP_001219140.1    Uniprot ID   A0AAX2LDD8
Organism   Streptococcus mitis NCTC 12261     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 328452..339716 333939..334685 within 0


Gene organization within MGE regions


Location: 328452..339716
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS01735 (SM12261_0336) - 328452..329084 (+) 633 WP_000756346.1 DJ-1/PfpI family protein -
  SM12261_RS01740 (SM12261_0337) dnaJ 329283..330419 (+) 1137 WP_001066310.1 molecular chaperone DnaJ -
  SM12261_RS01745 (SM12261_0338) - 330700..330987 (-) 288 WP_000777752.1 hypothetical protein -
  SM12261_RS01750 (SM12261_0339) - 330997..331407 (-) 411 WP_001278319.1 HIT family protein -
  SM12261_RS01755 (SM12261_0340) pptA 331475..332206 (+) 732 WP_000889948.1 ABC transporter ATP-binding protein Regulator
  SM12261_RS01760 (SM12261_0341) - 332203..333252 (+) 1050 WP_000653760.1 ABC transporter permease -
  SM12261_RS01765 (SM12261_0342) - 333314..333643 (-) 330 WP_000132585.1 hypothetical protein -
  SM12261_RS01770 (SM12261_0343) comE/blpR 333939..334685 (+) 747 WP_001219140.1 response regulator transcription factor Regulator
  SM12261_RS01775 (SM12261_0344) - 334690..336039 (+) 1350 WP_000409121.1 sensor histidine kinase -
  SM12261_RS01795 (SM12261_0346) - 337347..337751 (+) 405 WP_000846948.1 hypothetical protein -
  SM12261_RS01800 (SM12261_0347) - 337772..337999 (+) 228 WP_001093254.1 bacteriocin class II family protein -
  SM12261_RS01805 (SM12261_0348) - 338014..338334 (+) 321 WP_000645118.1 hypothetical protein -
  SM12261_RS01810 (SM12261_0349) - 338363..338767 (+) 405 WP_000717993.1 hypothetical protein -
  SM12261_RS01815 (SM12261_0350) blpZ 338826..339074 (+) 249 WP_000276515.1 immunity protein BlpZ -
  SM12261_RS01820 (SM12261_0351) - 339105..339716 (+) 612 WP_000394026.1 CPBP family intramembrane glutamic endopeptidase -

Sequence

Protein


Download         Length: 248 a.a.        Molecular weight: 29236.53 Da        Isoelectric Point: 6.5890

>NTDB_id=284630 SM12261_RS01770 WP_001219140.1 333939..334685(+) (comE/blpR) [Streptococcus mitis NCTC 12261]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKADQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEIYY
LETSPRAHRVILYTKTDRLEFTASLEEILKQEPRLLQCHRSFLINPANVIHLDKKEKLLFFPNGRSCLIARYKVREVSEA
INNLHLVR

Nucleotide


Download         Length: 747 bp        

>NTDB_id=284630 SM12261_RS01770 WP_001219140.1 333939..334685(+) (comE/blpR) [Streptococcus mitis NCTC 12261]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAAGAACA
TCATATCACTCCTAGCTCTTTTGAAGTCTTTGGGAAAGCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCGCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCTTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAGAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGATTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACGGACAGACTGGAATTTACAGCGAGTTTAGAGGA
GATTCTCAAGCAGGAGCCTCGTCTCCTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGATACATTTGGATA
AGAAAGAAAAACTCCTTTTCTTCCCCAATGGGAGAAGTTGCCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATCAATAACTTACACTTAGTGAGGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.144

97.984

0.54
  comE/comE1 Streptococcus equinus JB1

43.46

95.565

0.415
  comE/comE2 Streptococcus equinus JB1

37.603

97.581

0.367

Multiple sequence alignment