Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   SSA_RS11665 Genome accession   NC_009009
Coordinates   2383989..2385323 (-) Length   444 a.a.
NCBI ID   WP_011837729.1    Uniprot ID   A3CRD1
Organism   Streptococcus sanguinis SK36     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2378989..2390323
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSA_RS11645 (SSA_2377) - 2380324..2382909 (+) 2586 WP_011837728.1 YfhO family protein -
  SSA_RS11660 (SSA_2378) comE 2383219..2383983 (-) 765 WP_002899529.1 competence system response regulator transcription factor ComE Regulator
  SSA_RS11665 (SSA_2379) comD/comD1 2383989..2385323 (-) 1335 WP_011837729.1 competence system sensor histidine kinase ComD Regulator
  SSA_RS11670 (SSA_2394) - 2385351..2385458 (-) 108 WP_002905686.1 competence protein -
  SSA_RS11680 (SSA_2380) rlmH 2385755..2386234 (-) 480 WP_011837730.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SSA_RS11685 (SSA_2381) htrA 2386438..2387610 (+) 1173 WP_002901929.1 S1C family serine protease Regulator
  SSA_RS11690 (SSA_2382) spo0J 2387674..2388435 (+) 762 WP_033179249.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 51805.43 Da        Isoelectric Point: 6.4194

>NTDB_id=26351 SSA_RS11665 WP_011837729.1 2383989..2385323(-) (comD/comD1) [Streptococcus sanguinis SK36]
MSLEIIGLIIHPFINVAAFLVILSKITKIKHTRFFVSVCFGLEIIVPFIIAFLGHIFSFSSTIPSYTLSFFLPLFLVWYF
CRVEKIKKYQSFLLSFFLCLSIDSSTTFFSVIISSVLGDDFVAQYMGLFLTCINLISLFFMVKVIDIFDFRIDYLKRSFF
KSQILMISSLYAMNWLILNLSHWISNIKHFNSFSSMIATICFLAFLSTLVTFKDSREKYEKEERLRQKESEQLRLQEYTD
EIVRLYYEIKGFRHDYASMLTSMQVAIQTGDIKEIEHIYQEVLADANLNLRSDKYTVFDLNNVGDSALRSVMTETIFQAR
EHQIQLTFEVKDKVERLPIKLLDLVRIASILLNNAIESAIDSLEKIVHVSLVQLDDRTIFVVQNSRKEGKLDLEELYQPE
FSTKGENRGYGLNNIKEILDRYEFITLDTQIEPSNFTQILTIRR

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=26351 SSA_RS11665 WP_011837729.1 2383989..2385323(-) (comD/comD1) [Streptococcus sanguinis SK36]
ATGTCACTTGAAATAATTGGATTAATTATTCATCCTTTTATTAATGTAGCTGCATTTTTAGTTATTTTATCAAAAATCAC
TAAAATTAAGCATACTCGCTTTTTTGTATCTGTTTGCTTTGGTCTTGAGATTATAGTTCCGTTTATAATTGCTTTTTTAG
GACACATATTTTCATTTTCTAGCACAATTCCATCATATACACTGTCATTTTTTCTCCCTCTATTTTTAGTTTGGTATTTT
TGTAGAGTTGAAAAAATTAAAAAATATCAATCTTTCTTACTTTCCTTCTTTTTATGTCTGTCAATTGATAGTTCTACTAC
TTTCTTTTCTGTTATTATTTCATCTGTTTTAGGAGATGATTTTGTAGCTCAGTACATGGGCTTGTTTCTGACATGTATCA
ACTTAATATCCTTGTTCTTTATGGTAAAGGTTATTGATATTTTTGATTTCAGAATAGATTATCTTAAAAGAAGTTTCTTT
AAATCTCAGATTCTGATGATTAGTAGTTTATATGCAATGAATTGGCTGATTTTAAATCTCTCTCACTGGATTAGTAATAT
AAAGCATTTCAACAGTTTTAGCAGTATGATTGCTACTATTTGTTTCTTGGCCTTTCTTTCTACCTTGGTGACATTCAAGG
ACAGCCGTGAGAAATACGAGAAAGAAGAGCGTTTGCGTCAAAAAGAATCTGAACAGCTTCGACTTCAGGAATATACTGAT
GAAATTGTGAGATTGTACTATGAAATCAAAGGATTTCGTCATGATTATGCTAGCATGTTGACGAGTATGCAAGTGGCTAT
TCAAACTGGAGATATCAAGGAAATTGAGCACATTTATCAAGAGGTCTTGGCTGATGCAAATTTGAACCTGCGTTCAGATA
AATATACAGTTTTTGATTTGAATAATGTAGGAGATTCAGCTTTAAGGAGTGTCATGACTGAGACAATCTTTCAAGCGCGT
GAACATCAGATTCAGCTGACTTTTGAAGTTAAGGATAAAGTGGAACGCCTTCCAATCAAGTTGTTAGATCTGGTCAGAAT
TGCTAGTATTTTATTAAATAATGCTATTGAGAGTGCCATTGACAGCCTGGAAAAAATTGTCCATGTTTCTCTGGTTCAAC
TGGATGATAGAACCATTTTTGTTGTTCAAAATTCTCGTAAAGAAGGAAAATTGGATTTGGAAGAACTATATCAGCCAGAG
TTTTCAACTAAAGGAGAAAATAGAGGCTACGGATTGAATAACATCAAGGAAATTTTAGATAGATATGAATTTATCACTCT
TGATACACAAATTGAGCCAAGCAATTTTACACAGATTTTAACAATTAGGAGATAG

Domains

Predicted by InterProScan.

GHKL domain (HATPase_c_5)

(340-442)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A3CRD1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

53.333

84.459

0.45
  comD/comD2 Streptococcus gordonii strain NCTC7865

51.823

86.486

0.448
  comD Streptococcus mitis NCTC 12261

42.572

100

0.432
  comD/comD2 Streptococcus pneumoniae TIGR4

45.052

86.486

0.39
  comD/comD1 Streptococcus pneumoniae R6

44.792

86.486

0.387
  comD/comD1 Streptococcus pneumoniae Rx1

44.792

86.486

0.387
  comD/comD1 Streptococcus pneumoniae D39

44.792

86.486

0.387
  comD Streptococcus mitis SK321

43.188

87.613

0.378

Multiple sequence alignment