Detailed information NTG0263132

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: DV131_RS03025
• Genome accession: NZ_CP031246
• Coordinates: 547959..548711 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866075.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain M26368
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 542959..553711

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DV131_RS03000	-	543886..545139 (+)	1254	WP_000649625.1	IS110 family transposase	-
DV131_RS03005	-	545399..545941 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
DV131_RS03020	-	546302..547699 (+)	1398	WP_114865846.1	ISNCY-like element IS1202 family transposase	-
DV131_RS12055	-	547772..547897 (+)	126	WP_001258159.1	hypothetical protein	-
DV131_RS03025	comE	547959..548711 (-)	753	WP_000866075.1	competence system response regulator transcription factor ComE	Regulator
DV131_RS03030	comD/comD1	548708..550033 (-)	1326	WP_025169508.1	competence system sensor histidine kinase ComD	Regulator
DV131_RS03035	comC	550046..550186 (-)	141	WP_000799697.1	competence-stimulating peptide ComC	Regulator
DV131_RS03045	rlmH	550468..550947 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DV131_RS03050	htrA	551130..552311 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
DV131_RS03055	spo0J	552369..553127 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29930.26 Da
• Isoelectric Point: 6.5073

>NTDB_id=263132 DV131_RS03025 WP_000866075.1 547959..548711(-) (comE) [Streptococcus pneumoniae strain M26368]
MKVLILEDVIEHQVRLERILDEISKESNTPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQISALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHAQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=263132 DV131_RS03025 WP_000866075.1 547959..548711(-) (comE) [Streptococcus pneumoniae strain M26368]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATACTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTTGCTCAACTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTGACCTATAAATACCAGATATCAGCCCTAGATTT
TGTTGATAAGGATATCAACGATGAGATGTTTAAGAAGCGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATGCTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	98.8	100	0.988
comE	Streptococcus pneumoniae D39	98.8	100	0.988
comE	Streptococcus pneumoniae R6	98.8	100	0.988
comE	Streptococcus pneumoniae TIGR4	98.8	100	0.988
comE	Streptococcus mitis SK321	98	100	0.98
comE	Streptococcus mitis NCTC 12261	97.2	100	0.972
comE	Streptococcus infantis strain Atu-4	90	100	0.9
comE/comE2	Streptococcus gordonii strain NCTC7865	62.4	100	0.624
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.4	100	0.624
comE/blpR	Streptococcus mutans UA159	40.891	98.8	0.404