Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   CWI64_RS05240 Genome accession   NZ_CP025076
Coordinates   972965..974221 (-) Length   418 a.a.
NCBI ID   WP_000642709.1    Uniprot ID   A0A0E8AGF5
Organism   Streptococcus pneumoniae strain BHN97x     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 965843..988057 972965..974221 within 0


Gene organization within MGE regions


Location: 965843..988057
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI64_RS05195 (CWI64_05195) - 965843..966637 (-) 795 WP_001101210.1 hypothetical protein -
  CWI64_RS05200 (CWI64_05200) - 967045..967470 (-) 426 WP_100931676.1 hypothetical protein -
  CWI64_RS05205 (CWI64_05205) - 967599..967958 (-) 360 WP_000749819.1 hypothetical protein -
  CWI64_RS05210 (CWI64_05210) - 968004..968210 (-) 207 WP_000366093.1 hypothetical protein -
  CWI64_RS05215 (CWI64_05215) - 968197..968358 (-) 162 WP_000289348.1 helix-turn-helix transcriptional regulator -
  CWI64_RS05220 (CWI64_05220) lytA 968736..969692 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  CWI64_RS05225 (CWI64_05225) - 970068..971438 (-) 1371 WP_001036255.1 MATE family efflux transporter -
  CWI64_RS05235 (CWI64_05235) recA 971744..972910 (-) 1167 WP_001085461.1 recombinase RecA Machinery gene
  CWI64_RS05240 (CWI64_05240) cinA 972965..974221 (-) 1257 WP_000642709.1 competence/damage-inducible protein A Machinery gene
  CWI64_RS05245 (CWI64_05245) - 974306..975322 (-) 1017 WP_000239282.1 LCP family protein -
  CWI64_RS05250 (CWI64_05250) - 975330..975848 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  CWI64_RS05255 (CWI64_05255) tsaE 975838..976281 (-) 444 WP_000288232.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  CWI64_RS05260 (CWI64_05260) comM 976367..976987 (-) 621 WP_000839908.1 hypothetical protein Regulator
  CWI64_RS05270 (CWI64_05270) - 977370..978233 (-) 864 WP_001093624.1 helix-turn-helix transcriptional regulator -
  CWI64_RS12290 (CWI64_05275) - 978425..978595 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  CWI64_RS05280 (CWI64_05280) pneA1 978698..978922 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  CWI64_RS05285 (CWI64_05285) pneA2 978929..979117 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  CWI64_RS11655 lanM 979234..981165 (+) 1932 WP_001812208.1 type 2 lanthipeptide synthetase LanM -
  CWI64_RS11660 - 981215..982225 (+) 1011 WP_001812207.1 lanthionine synthetase LanC family protein -
  CWI64_RS05295 (CWI64_05295) - 982575..983279 (+) 705 WP_001033170.1 flavodoxin family protein -
  CWI64_RS05300 (CWI64_05300) - 983260..984189 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  CWI64_RS05305 (CWI64_05305) - 984186..986294 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  CWI64_RS05310 (CWI64_05310) - 986318..988057 (+) 1740 WP_000699969.1 S8 family serine peptidase -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45075.48 Da        Isoelectric Point: 4.6064

>NTDB_id=258082 CWI64_RS05240 WP_000642709.1 972965..974221(-) (cinA) [Streptococcus pneumoniae strain BHN97x]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQI
LDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFKGGFVTYSLEEKSRML
DIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQEQGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=258082 CWI64_RS05240 WP_000642709.1 972965..974221(-) (cinA) [Streptococcus pneumoniae strain BHN97x]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAACACCAATGCCCAGTTTTTGTCGGA
AAAACTAGCTGAGATTGGGGTAGATGTATATTTTCAGACGGCTGTAGGAGACAATGAAGTTCGTCTCTTGTCTTTGCTTG
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGCGGTTTGGGGCCAACTGAGGACGACCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGCATTAGTCTTTGATCCTCAGGCTCAGGAGAAGTTGGATATCTTTTTTGCCCTGCGACC
AGACTATGCCCGAACACCGAATAACGAAAGACAAGCTCAAATTGTAGAAGGAGCGATTCCACTGCCAAACGAAACAGGAC
TGGCTGTTGGAGGAAAATTAGAAGTAGACGGAGTGACCTATGTCGTCCTTCCAGGTCCGCCAAGTGAATTGAAACCCATG
GTCTTAAACCAACTTCTACCCAAGTTGATGACAGGGAGCAAGCTGTATTCCCGAGTTCTTCGTTTCTTTGGGATTGGCGA
GAGCCAGCTGGTTACGATTTTGGCTGATTTAATTGATAATCAGATCGATCCTACCTTGGCCCCTTATGCCAAGACAGGAG
AAGTCACTCTACGTCTGTCAACAAAGGCTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTGGAAAATCAAATC
TTGGACTGCCAGACTTTCGAAGGAATTTCTTTACGAGACTTTTGCTATGGTTATGGGGAAGAAACTAGTTTAGCCAGCAT
TGTGGTAGAAGAACTGAAAAGGCAAGGGAAAACCATCGCGGCTGCAGAGAGTTTGACGGCAGGTCTTTTCCAAGCTACCG
TGGCGAATTTTTCTGGAGTTTCAAGTATATTTAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGAATTTGGAAGAACATGGTGTGGTGTCTGAATTTACAGCTCAGAAGATGGCTGAGCAGGCACGAAG
CAAGACCCAGTCTGATTTTGGAATTAGTTTGACCGGAGTGGCAGGACCAGATAGCCTAGAAGGACACCCAGTTGGGACAG
TCTTCATAGGCTTGGCGCAAGAGCAAGGAACTGAGGTTATCAAGGTTAATATTGGAGGCAGAAGCCGAGCAGATGTACGT
CATATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(262-414)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E8AGF5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus pneumoniae TIGR4

99.522

100

0.995
  cinA Streptococcus pneumoniae Rx1

99.282

100

0.993
  cinA Streptococcus pneumoniae R6

99.282

100

0.993
  cinA Streptococcus pneumoniae D39

99.043

100

0.99
  cinA Streptococcus mitis SK321

94.019

100

0.94
  cinA Streptococcus mitis NCTC 12261

93.78

100

0.938
  cinA Streptococcus mutans UA159

71.053

100

0.711
  cinA Streptococcus suis isolate S10

55.048

99.522

0.548
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment