Detailed information NTG0257606

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: CWI26_RS05180
• Genome accession: NZ_CP025043
• Coordinates: 1043221..1043892 (+)
• Length: 223 a.a.
• NCBI ID: WP_002940863.1
• Uniprot ID: A0A2I5N3I8
• Organism: Streptococcus suis strain AH681
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1038221..1048892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CWI26_RS05150 (CWI26_05150)	pstC	1038471..1039388 (+)	918	WP_100881326.1	phosphate ABC transporter permease subunit PstC	-
CWI26_RS05155 (CWI26_05155)	pstA	1039378..1040265 (+)	888	WP_044757644.1	phosphate ABC transporter permease PstA	-
CWI26_RS05160 (CWI26_05160)	pstB	1040290..1041093 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
CWI26_RS05165 (CWI26_05165)	pstB	1041105..1041863 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
CWI26_RS05170 (CWI26_05170)	phoU	1041892..1042548 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
CWI26_RS05175 (CWI26_05175)	-	1042698..1043075 (+)	378	WP_100881327.1	hypothetical protein	-
CWI26_RS05180 (CWI26_05180)	ciaR	1043221..1043892 (+)	672	WP_002940863.1	response regulator transcription factor	Regulator
CWI26_RS05185 (CWI26_05185)	ciaH	1043885..1045264 (+)	1380	WP_029187994.1	sensor histidine kinase	Regulator
CWI26_RS05190 (CWI26_05190)	-	1045365..1046594 (+)	1230	WP_029176022.1	transglutaminase domain-containing protein	-
CWI26_RS05195 (CWI26_05195)	rpsT	1046822..1047070 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
CWI26_RS05200 (CWI26_05200)	coaA	1047129..1048049 (-)	921	WP_002940857.1	type I pantothenate kinase	-
CWI26_RS05205 (CWI26_05205)	-	1048158..1048748 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25261.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=257606 CWI26_RS05180 WP_002940863.1 1043221..1043892(+) (ciaR) [Streptococcus suis strain AH681]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=257606 CWI26_RS05180 WP_002940863.1 1043221..1043892(+) (ciaR) [Streptococcus suis strain AH681]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGTCTTTCGAATTCTGTTTTTGATTTTCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGCCTTGAAGATAAAGGTCACGGATTTGAATTAGGTGCAGATGATTATTTGACCAAGCCATTTTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCCTTATTAAAGAGATCGGGCAAGTTTAATGAAAACACACTGACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACGACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A2I5N3I8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.583	100	0.906
ciaR	Streptococcus pneumoniae Rx1	89.238	100	0.892
ciaR	Streptococcus pneumoniae D39	89.238	100	0.892
ciaR	Streptococcus pneumoniae R6	89.238	100	0.892
ciaR	Streptococcus pneumoniae TIGR4	89.238	100	0.892
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.611	100	0.381
vicR	Streptococcus mutans UA159	35.897	100	0.377
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.363