Detailed information NTG0257607

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: CWI26_RS05185
• Genome accession: NZ_CP025043
• Coordinates: 1043885..1045264 (+)
• Length: 459 a.a.
• NCBI ID: WP_029187994.1
• Uniprot ID: A0A2I5N3K8
• Organism: Streptococcus suis strain AH681
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1038885..1050264

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CWI26_RS05155 (CWI26_05155)	pstA	1039378..1040265 (+)	888	WP_044757644.1	phosphate ABC transporter permease PstA	-
CWI26_RS05160 (CWI26_05160)	pstB	1040290..1041093 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
CWI26_RS05165 (CWI26_05165)	pstB	1041105..1041863 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
CWI26_RS05170 (CWI26_05170)	phoU	1041892..1042548 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
CWI26_RS05175 (CWI26_05175)	-	1042698..1043075 (+)	378	WP_100881327.1	hypothetical protein	-
CWI26_RS05180 (CWI26_05180)	ciaR	1043221..1043892 (+)	672	WP_002940863.1	response regulator transcription factor	Regulator
CWI26_RS05185 (CWI26_05185)	ciaH	1043885..1045264 (+)	1380	WP_029187994.1	sensor histidine kinase	Regulator
CWI26_RS05190 (CWI26_05190)	-	1045365..1046594 (+)	1230	WP_029176022.1	transglutaminase domain-containing protein	-
CWI26_RS05195 (CWI26_05195)	rpsT	1046822..1047070 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
CWI26_RS05200 (CWI26_05200)	coaA	1047129..1048049 (-)	921	WP_002940857.1	type I pantothenate kinase	-
CWI26_RS05205 (CWI26_05205)	-	1048158..1048748 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-
CWI26_RS05210 (CWI26_05210)	-	1048745..1050022 (+)	1278	WP_024413752.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 459 a.a.
• Molecular weight: 52038.74 Da
• Isoelectric Point: 6.5307

>NTDB_id=257607 CWI26_RS05185 WP_029187994.1 1043885..1045264(+) (ciaH) [Streptococcus suis strain AH681]
MPKRFKKLMYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQNSDNTLKRIKEEPVMAVGFAIARTYEPNSVFILQD
SPTSEETTSSSSDSMPVPKEQKNTRDGDQLRLGVNTHVLLYSKSGEMVNPDTFTGLADLPLDKEKLGEIKEAKVESSFGM
SEDYRYVTIELATDELGYYSSYDIKYATILVNVSQIKSSIETYESTVAIVMVSAWLISILASIYLSNLSMRPILISYQKQ
KDFVENASHELRTPLAVLQNRLESLFRHPEATILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGLKVDMIDVQPNYFD
EIFANYLMIAEENGKTLTVNNLIHQPIRTDKVLIKQLLTILFDNAMKYTDDDGRIQITANIKDKSVYFTVADNGLGISDA
DKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKTLGGKISVRDNQPKGTIFEVGLPK

Nucleotide

• Length: 1380 bp

>NTDB_id=257607 CWI26_RS05185 WP_029187994.1 1043885..1045264(+) (ciaH) [Streptococcus suis strain AH681]
ATGCCTAAGCGATTTAAAAAATTAATGTACACGGATAAATTTTCCTTCTTTATCCGTTATTTTGCAGTATTTACCCTGAT
TTTTGGCTTGATGACAGCTATCATTTTTCAATTAATGCGTTCAACTATGTATCAAAATTCAGATAATACCTTGAAACGGA
TTAAGGAAGAACCAGTGATGGCTGTTGGTTTTGCGATCGCAAGAACCTATGAGCCCAACTCTGTCTTTATCCTTCAAGAT
AGCCCAACTAGTGAAGAAACGACGAGCTCTAGCTCAGATAGCATGCCTGTTCCTAAAGAACAAAAAAATACTAGAGATGG
AGATCAGCTGAGATTAGGTGTCAATACTCATGTCTTACTCTATAGTAAAAGTGGAGAAATGGTCAATCCGGATACTTTTA
CTGGTTTGGCCGACCTACCGTTAGATAAGGAAAAATTGGGCGAAATTAAGGAAGCAAAGGTTGAATCAAGCTTCGGTATG
TCTGAAGATTATCGCTATGTGACGATTGAGCTGGCTACAGATGAACTAGGTTATTATTCGTCCTATGATATAAAATATGC
GACAATTTTAGTGAATGTCAGCCAAATAAAATCCTCCATTGAGACCTATGAATCGACAGTTGCTATTGTTATGGTTTCAG
CTTGGCTCATTTCTATCTTAGCCAGTATTTACCTATCGAATCTTAGCATGCGTCCAATTCTAATTAGCTATCAAAAGCAA
AAAGACTTTGTTGAAAATGCTAGTCATGAGTTGCGTACGCCGTTGGCTGTTCTCCAAAATCGCTTGGAGAGCCTGTTTCG
CCATCCCGAAGCGACGATTTTAGAGAGTAGTGAAAGCATCGGATCTAGTTTGGAAGAAGTTCGAAATATGCGATTATTGA
CAACGAACCTACTCAATTTGGCTCGTCGTGATGATGGCTTAAAAGTCGATATGATTGATGTCCAACCCAACTATTTTGAT
GAAATCTTTGCTAATTACCTTATGATTGCTGAAGAAAATGGAAAAACACTAACAGTTAATAATTTGATTCATCAGCCGAT
TCGAACAGACAAGGTCCTGATTAAACAGTTGCTTACCATTTTATTTGACAATGCCATGAAGTATACCGACGATGATGGCA
GAATTCAAATTACAGCTAATATCAAGGATAAATCTGTCTACTTCACAGTTGCCGACAATGGTTTGGGAATCAGCGATGCT
GATAAGAAGAAAATCTTTGATCGCTTTTATCGAGTTGATAAGGCCAGAACGCGTCAAAAAGGTGGTTTCGGTCTAGGATT
ATCGCTGGCTCAGCAAATTATCAAGACACTAGGTGGGAAAATCTCTGTTAGAGATAACCAACCGAAAGGAACTATTTTTG
AGGTAGGATTACCTAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (240-306)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (350-458)

3D structure

• AlphaFold DB: A0A2I5N3K8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	50	99.782	0.499
ciaH	Streptococcus pneumoniae D39	50	99.782	0.499
ciaH	Streptococcus pneumoniae R6	50	99.782	0.499
ciaH	Streptococcus pneumoniae TIGR4	50	99.782	0.499
ciaH	Streptococcus mutans UA159	49.67	99.129	0.492