Detailed information NTG0256930

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: CVO91_RS05300
• Genome accession: NZ_CP024974
• Coordinates: 1037092..1037763 (+)
• Length: 223 a.a.
• NCBI ID: WP_002940863.1
• Uniprot ID: A0A2I5N3I8
• Organism: Streptococcus suis strain CZ130302
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1032092..1042763

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CVO91_RS05270 (CVO91_05270)	pstC	1032313..1033230 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
CVO91_RS05275 (CVO91_05275)	pstA	1033220..1034107 (+)	888	WP_002940867.1	phosphate ABC transporter permease PstA	-
CVO91_RS05280 (CVO91_05280)	pstB	1034132..1034935 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
CVO91_RS05285 (CVO91_05285)	pstB	1034947..1035705 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
CVO91_RS05290 (CVO91_05290)	phoU	1035734..1036390 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
CVO91_RS05295 (CVO91_05295)	-	1036540..1036947 (+)	408	WP_100664799.1	hypothetical protein	-
CVO91_RS05300 (CVO91_05300)	ciaR	1037092..1037763 (+)	672	WP_002940863.1	response regulator transcription factor	Regulator
CVO91_RS05305 (CVO91_05305)	ciaH	1037756..1039135 (+)	1380	WP_033875427.1	HAMP domain-containing sensor histidine kinase	Regulator
CVO91_RS05310 (CVO91_05310)	-	1039236..1040465 (+)	1230	WP_002940861.1	transglutaminase domain-containing protein	-
CVO91_RS05315 (CVO91_05315)	rpsT	1040718..1040966 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
CVO91_RS05320 (CVO91_05320)	coaA	1041025..1041945 (-)	921	WP_002940857.1	type I pantothenate kinase	-
CVO91_RS05325 (CVO91_05325)	-	1042054..1042644 (+)	591	WP_002940854.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25261.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=256930 CVO91_RS05300 WP_002940863.1 1037092..1037763(+) (ciaR) [Streptococcus suis strain CZ130302]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=256930 CVO91_RS05300 WP_002940863.1 1037092..1037763(+) (ciaR) [Streptococcus suis strain CZ130302]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TACCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGATCGGGCAAGTTTAATGAAAACACACTGACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTGCCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A2I5N3I8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.583	100	0.906
ciaR	Streptococcus pneumoniae Rx1	89.238	100	0.892
ciaR	Streptococcus pneumoniae D39	89.238	100	0.892
ciaR	Streptococcus pneumoniae R6	89.238	100	0.892
ciaR	Streptococcus pneumoniae TIGR4	89.238	100	0.892
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.611	100	0.381
vicR	Streptococcus mutans UA159	35.897	100	0.377
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.363