Detailed information NTG0247990

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: CO687_RS08305
• Genome accession: NZ_CP023511
• Coordinates: 1683433..1684107 (-)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain FDAARGOS_371
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1678433..1689107

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CO687_RS08280 (CO687_08280)	coaA	1678482..1679402 (+)	921	WP_045634868.1	type I pantothenate kinase	-
CO687_RS08285 (CO687_08285)	rpsT	1679499..1679747 (+)	249	WP_008808726.1	30S ribosomal protein S20	-
CO687_RS08290 (CO687_08290)	-	1679812..1680321 (+)	510	WP_008808727.1	DNA topology modulation protein	-
CO687_RS08295 (CO687_08295)	-	1680437..1681888 (+)	1452	WP_172858962.1	alpha-amylase	-
CO687_RS08300 (CO687_08300)	ciaH	1682037..1683443 (-)	1407	WP_096755252.1	HAMP domain-containing sensor histidine kinase	Regulator
CO687_RS08305 (CO687_08305)	ciaR	1683433..1684107 (-)	675	WP_008808730.1	response regulator transcription factor	Regulator
CO687_RS08310 (CO687_08310)	-	1684238..1684693 (-)	456	WP_096755253.1	hypothetical protein	-
CO687_RS08315 (CO687_08315)	-	1684877..1685680 (-)	804	WP_061593323.1	SDR family NAD(P)-dependent oxidoreductase	-
CO687_RS08320 (CO687_08320)	-	1685695..1686021 (-)	327	WP_096755254.1	multidrug efflux SMR transporter	-
CO687_RS08325 (CO687_08325)	-	1686072..1686356 (-)	285	WP_096755255.1	helix-turn-helix transcriptional regulator	-
CO687_RS08330 (CO687_08330)	-	1686539..1689082 (-)	2544	WP_096755256.1	M1 family metallopeptidase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=247990 CO687_RS08305 WP_008808730.1 1683433..1684107(-) (ciaR) [Streptococcus gordonii strain FDAARGOS_371]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=247990 CO687_RS08305 WP_008808730.1 1683433..1684107(-) (ciaR) [Streptococcus gordonii strain FDAARGOS_371]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGACTCTATGAAGCCGAAAGCGGTGTTTATGATTTGATTTTACTTGATCTGATGC
TCCCTGAAAAAGATGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTAGATGATAAAGGGCATGGTTTTGAATTGGGTGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAAGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACCTTATCATATGGTGATGTAACAG
TAAACCTCTCTACCAATACCACATTGGTGAACGGAAAAGAAGTAGAATTACTAGGAAAAGAATTTGATTTATTAGTTTAT
TTCTTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGACTCTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTCGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362